rdf:type |
|
lifeskim:mentions |
umls-concept:C0007301,
umls-concept:C0012544,
umls-concept:C0026336,
umls-concept:C0034493,
umls-concept:C0087111,
umls-concept:C0205374,
umls-concept:C0331858,
umls-concept:C0333117,
umls-concept:C0443252,
umls-concept:C0524975,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C2267018
|
pubmed:issue |
10
|
pubmed:dateCreated |
2004-9-9
|
pubmed:abstractText |
Bisphosphonates induce major increases in strength of callus in distraction osteogenesis in the short term. Poor understanding of the underlying mechanism, however, raises concerns about long-term consequences. In this long-term study in 32 rabbits, zoledronic acid transiently increased trabeculae by delayed temporal progression of endochondral bone remodeling but did not prevent radiographic completion of bone repair.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0884-0431
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
19
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1698-705
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15355565-Acid Phosphatase,
pubmed-meshheading:15355565-Animals,
pubmed-meshheading:15355565-Bone Density,
pubmed-meshheading:15355565-Bone Regeneration,
pubmed-meshheading:15355565-Bony Callus,
pubmed-meshheading:15355565-Cartilage,
pubmed-meshheading:15355565-Diphosphonates,
pubmed-meshheading:15355565-Disease Models, Animal,
pubmed-meshheading:15355565-Imidazoles,
pubmed-meshheading:15355565-Isoenzymes,
pubmed-meshheading:15355565-Male,
pubmed-meshheading:15355565-Osteoblasts,
pubmed-meshheading:15355565-Osteoclasts,
pubmed-meshheading:15355565-Osteogenesis, Distraction,
pubmed-meshheading:15355565-Rabbits,
pubmed-meshheading:15355565-Tibia,
pubmed-meshheading:15355565-Time Factors
|
pubmed:year |
2004
|
pubmed:articleTitle |
Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogenesis.
|
pubmed:affiliation |
Orthopaedic Research Unit, Children's Hospital at Westmead, Sydney, Australia. e.smith@garvan.org.au
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|