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pubmed-article:15355555pubmed:abstractTextWe analyzed the association between the IL-6 G-174C polymorphism and osteoporosis phenotypes in 3376 older women. Women with the C/C genotype had a significantly slower rate of decline in hip BMD and a 33% lower risk of wrist fracture than women with the G/G genotype. Variation at the IL-6 locus may contribute to the genetic susceptibility to bone fragility.lld:pubmed
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pubmed-article:15355555pubmed:articleTitleAssociation of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women.lld:pubmed
pubmed-article:15355555pubmed:affiliationDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Susan.moffett@hgen.pitt.edulld:pubmed
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