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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-9-9
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pubmed:abstractText |
We analyzed the association between the IL-6 G-174C polymorphism and osteoporosis phenotypes in 3376 older women. Women with the C/C genotype had a significantly slower rate of decline in hip BMD and a 33% lower risk of wrist fracture than women with the G/G genotype. Variation at the IL-6 locus may contribute to the genetic susceptibility to bone fragility.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0884-0431
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pubmed:author |
pubmed-author:CauleyJane AJA,
pubmed-author:CummingsSteven RSR,
pubmed-author:EnsrudKristine EKE,
pubmed-author:HillierTeresa ATA,
pubmed-author:HochbergMarc CMC,
pubmed-author:JoslynGeoffG,
pubmed-author:MoffettSusan PSP,
pubmed-author:MorinPhillipP,
pubmed-author:NevittMichael CMC,
pubmed-author:SOF Research Group,
pubmed-author:StoneKatie LKL,
pubmed-author:ZmudaJoseph MJM
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1612-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15355555-Aged,
pubmed-meshheading:15355555-Bone Density,
pubmed-meshheading:15355555-Female,
pubmed-meshheading:15355555-Genetic Predisposition to Disease,
pubmed-meshheading:15355555-Genotype,
pubmed-meshheading:15355555-Hip Joint,
pubmed-meshheading:15355555-Humans,
pubmed-meshheading:15355555-Interleukin-6,
pubmed-meshheading:15355555-Osteoporosis, Postmenopausal,
pubmed-meshheading:15355555-Polymorphism, Genetic,
pubmed-meshheading:15355555-Promoter Regions, Genetic,
pubmed-meshheading:15355555-Prospective Studies,
pubmed-meshheading:15355555-Radius Fractures,
pubmed-meshheading:15355555-Risk Factors,
pubmed-meshheading:15355555-United States
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pubmed:year |
2004
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pubmed:articleTitle |
Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women.
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pubmed:affiliation |
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Susan.moffett@hgen.pitt.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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