Linked Life Data

15354859

Source:http://linkedlifedata.com/resource/pubmed/id/15354859

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-9-9
pubmed:abstractText
Genetic contributions play an important role in determining bone mineral density (BMD) and bone turnover. Transforming growth factor-beta (TGF-beta) is abundant in bone and has been implicated as an important regulator of both bone formation and resorption. Several polymorphisms of the TGF-beta1 gene have recently been suggested to be associated with BMD and susceptibility to osteoporotic spine fractures. To determine the relationship between TGF-beta1 polymorphisms and BMD in southern Chinese women, three SNPs at C(-1348) -T, T29 -C, and T(861-20) -C of TGF-beta1 gene were analyzed in 237 postmenopausal southern Chinese women by RFLP and direct sequencing. BMD at the lumbar spine and hip region, biochemical markers of bone turnover, as well as serum levels of TGF-beta1 were measured. Only the T29 -C polymorphism of TGF-beta1 gene was associated with BMD and fracture risk. The prevalence of fragility fractures was significantly higher in individuals with TC genotype (P < 0.05). Serum alkaline phosphatase and osteocalcin levels as well as urinary N-telopeptide excretion were significantly higher in women with TC than with TT or CC genotypes, and the difference remained significant after adjusting for age and BMI (all P < 0.05). Women with TC genotype had lower BMD at the trochanteric (P < 0.03) and total hip region (P = 0.05). No difference was observed in the serum TGF-beta1 levels among the three genotypes. In conclusion, an association between T29 -C polymorphisms of TGF-beta1 gene and BMD, bone turnover as well as fragility fractures were demonstrated in postmenopausal southern Chinese women.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0171-967X
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
516-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15354859-Aged, pubmed-meshheading:15354859-Asian Continental Ancestry Group, pubmed-meshheading:15354859-Biological Markers, pubmed-meshheading:15354859-Bone Density, pubmed-meshheading:15354859-Bone Remodeling, pubmed-meshheading:15354859-Bone and Bones, pubmed-meshheading:15354859-Female, pubmed-meshheading:15354859-Fractures, Bone, pubmed-meshheading:15354859-Hong Kong, pubmed-meshheading:15354859-Humans, pubmed-meshheading:15354859-Osteoporosis, Postmenopausal, pubmed-meshheading:15354859-Polymerase Chain Reaction, pubmed-meshheading:15354859-Polymorphism, Genetic, pubmed-meshheading:15354859-Polymorphism, Restriction Fragment Length, pubmed-meshheading:15354859-Risk, pubmed-meshheading:15354859-Transforming Growth Factor beta, pubmed-meshheading:15354859-Transforming Growth Factor beta1
pubmed:year
2004
pubmed:articleTitle
Transforming growth factor-beta1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern Chinese women.
pubmed:affiliation
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, PRC.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't