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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-9-14
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pubmed:abstractText |
In the monocrotaline (MCT)-treated rat, there is marked stimulation of DNA synthesis and megalocytosis of pulmonary arterial endothelial cells (PAECs) within 3 to 4 days, followed by pulmonary hypertension (PH) 10 to 14 days later. Growing evidence implicates caveolin-1 (cav-1) in plasma membrane rafts as a negative regulator of promitogenic signaling. We have investigated the integrity and function of endothelial cell-selective cav-1alpha/raft signaling in MCT-induced PH.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD31,
http://linkedlifedata.com/resource/pubmed/chemical/Cav protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolin 1,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Grp58 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Isomerases,
http://linkedlifedata.com/resource/pubmed/chemical/Monocrotaline,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Disulfide-Isomerases,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/monocrotaline pyrrole,
http://linkedlifedata.com/resource/pubmed/chemical/von Willebrand Factor
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1499-506
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pubmed:dateRevised |
2010-4-29
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pubmed:meshHeading |
pubmed-meshheading:15353500-Animals,
pubmed-meshheading:15353500-Antigens, CD31,
pubmed-meshheading:15353500-Caveolin 1,
pubmed-meshheading:15353500-Caveolins,
pubmed-meshheading:15353500-DNA-Binding Proteins,
pubmed-meshheading:15353500-Disease Models, Animal,
pubmed-meshheading:15353500-Endothelial Cells,
pubmed-meshheading:15353500-Endothelium, Vascular,
pubmed-meshheading:15353500-Heat-Shock Proteins,
pubmed-meshheading:15353500-Hypertension, Pulmonary,
pubmed-meshheading:15353500-Hypertrophy, Right Ventricular,
pubmed-meshheading:15353500-Isomerases,
pubmed-meshheading:15353500-Male,
pubmed-meshheading:15353500-Membrane Microdomains,
pubmed-meshheading:15353500-Mitosis,
pubmed-meshheading:15353500-Monocrotaline,
pubmed-meshheading:15353500-Phosphorylation,
pubmed-meshheading:15353500-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:15353500-Protein Disulfide-Isomerases,
pubmed-meshheading:15353500-Protein Processing, Post-Translational,
pubmed-meshheading:15353500-Pulmonary Artery,
pubmed-meshheading:15353500-Rats,
pubmed-meshheading:15353500-Rats, Sprague-Dawley,
pubmed-meshheading:15353500-STAT3 Transcription Factor,
pubmed-meshheading:15353500-Trans-Activators,
pubmed-meshheading:15353500-von Willebrand Factor
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pubmed:year |
2004
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pubmed:articleTitle |
Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension.
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pubmed:affiliation |
Department of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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