|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0017296,
umls-concept:C0086418,
umls-concept:C0185125,
umls-concept:C0555198,
umls-concept:C0596988,
umls-concept:C0598086,
umls-concept:C0598388,
umls-concept:C1415887,
umls-concept:C1419040,
umls-concept:C1420433,
umls-concept:C1424666
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|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2004-9-8
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|
pubmed:abstractText |
Malignant glioma could be an ideal candidate for local gene therapy because its invasion is local and it has little metastatic potential. A low expression level and high degradation activity of p27 are known to constitute an independent poor prognostic factor in patients with malignant glioma. In this study, the authors investigated the roles of wild-type p27 and mutant p27 on the treatment of malignant glioma.
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pubmed:language |
eng
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|
pubmed:journal |
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|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-3085
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
101
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
505-10
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15352609-Adenoviridae,
pubmed-meshheading:15352609-Apoptosis,
pubmed-meshheading:15352609-Brain Neoplasms,
pubmed-meshheading:15352609-Cell Cycle,
pubmed-meshheading:15352609-Cell Cycle Proteins,
pubmed-meshheading:15352609-Cell Division,
pubmed-meshheading:15352609-Cell Line, Tumor,
pubmed-meshheading:15352609-Cell Survival,
pubmed-meshheading:15352609-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:15352609-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15352609-Gene Therapy,
pubmed-meshheading:15352609-Gene Transfer Techniques,
pubmed-meshheading:15352609-Genes, Tumor Suppressor,
pubmed-meshheading:15352609-Glioblastoma,
pubmed-meshheading:15352609-Humans,
pubmed-meshheading:15352609-Mutagenesis, Site-Directed,
pubmed-meshheading:15352609-Threonine,
pubmed-meshheading:15352609-Transduction, Genetic,
pubmed-meshheading:15352609-Tumor Cells, Cultured,
pubmed-meshheading:15352609-Tumor Stem Cell Assay,
pubmed-meshheading:15352609-Tumor Suppressor Proteins
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
Application of p27 gene therapy for human malignant glioma potentiated by using mutant p27.
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|
pubmed:affiliation |
Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
