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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-1-14
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pubmed:abstractText |
Decreased diaphragmatic contractility and organ failure observed during sepsis is mediated by an overproduction of nitric oxide ((.)NO)-derived species, mitochondria being a major target of oxidative and nitrative stress. We tested the potential protective effects of (a) a novel synthetic antioxidant, the manganese(III) 5,10,15,20-tetrakis(N-ethylpyridinium-2-yl) porphyrin (MnTE-2-PyP(5+)) and (b) the inducible (.)NO synthase inhibitor aminoguanidine (AG) on a rat model of sepsis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0342-4642
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pubmed:author |
pubmed-author:AlfonsoEvangelinaE,
pubmed-author:BatthyányCarlosC,
pubmed-author:BoggiaJoséJ,
pubmed-author:BottiHoracioH,
pubmed-author:CassinaAdrianaA,
pubmed-author:HurtadoF JavierFJ,
pubmed-author:NinNicolásN,
pubmed-author:PeluffoGonzaloG,
pubmed-author:RadiRafaelR,
pubmed-author:RubboHomeroH,
pubmed-author:TrostchanskyAndrésA
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2271-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15349724-Animals,
pubmed-meshheading:15349724-Blood Pressure,
pubmed-meshheading:15349724-Diaphragm,
pubmed-meshheading:15349724-Enzyme Inhibitors,
pubmed-meshheading:15349724-Guanidines,
pubmed-meshheading:15349724-Heart Rate,
pubmed-meshheading:15349724-Male,
pubmed-meshheading:15349724-Metalloporphyrins,
pubmed-meshheading:15349724-Mitochondria, Heart,
pubmed-meshheading:15349724-Muscle Contraction,
pubmed-meshheading:15349724-Nitric Oxide Synthase,
pubmed-meshheading:15349724-Oxidative Stress,
pubmed-meshheading:15349724-Oxygen Consumption,
pubmed-meshheading:15349724-Pulmonary Gas Exchange,
pubmed-meshheading:15349724-Rats,
pubmed-meshheading:15349724-Rats, Inbred WKY,
pubmed-meshheading:15349724-Sepsis
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pubmed:year |
2004
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pubmed:articleTitle |
Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition.
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pubmed:affiliation |
Department of Pathophysiology, Hospital de Clínicas, School of Medicine, Universidad de la República , Avenida Italia s/n, Piso 15, CP 11600 Montevideo, Uruguay.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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