Linked Life Data

15348944

Source:http://linkedlifedata.com/resource/pubmed/id/15348944

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2004-9-6
pubmed:abstractText
The synthesis, characterization and properties of new acrylic "polymeric drugs" derived from the NSAIDs agents ibuprofen and ketoprofen are described. The swelling behavior in hydrated medium and the controlled release from hydrophilic copolymers of the NSAIDs derivatives and 2-hydroxyethylmethacrylate, HEMA, are discussed, considering the hydrolytical reactivity of the acrylamide or acrylic ester functional groups, the aromatic or aliphatic structure of the spacer side groups, and the hydrophilic character of the copolymer systems. The results obtained demonstrated that the swelling degree of copolymers depends on the average composition of copolymers, decreasing with the increase of the average fraction of the corresponding acrylic derivative of ibuprofen or ketoprofen in the copolymer system. In addition, polymers which support the NSAIDs active component through aromatic amide links, are more sensitive to hydrolytical processes than those of alkyl ester functions. The results obtained demonstrate that these supports could be applied for direct administration, transdermal, systemic or intra-articular injection, as well as in the form of films on wounds.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Dec
pubmed:issn
0957-4530
pubmed:author
pubmed:copyrightInfo
Copyright 1998 Kluwer Academic Publishers
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
803-9
pubmed:year
1998
pubmed:articleTitle
Controlled release of NSAIDs bound to polyacrylic carrier systems.
pubmed:affiliation
Instituto de C.y T. de Poímeros, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain. ictsr04@fresno.csic.es
pubmed:publicationType
Journal Article