Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1992-7-14
|
| pubmed:abstractText |
Grafting of thymic anlagen from day-10 DBA/2 (H-2d; Mls-1a) embryos to newborn athymic BALB/c (H-2d; Mls-1b) mice leads to reconstitution of T cell populations in the recipients. Analysis of adult chimeras shows that their V beta T cell receptor (TcR) repertoires, particularly V beta 6 and V beta 8.1, do not significantly differ in most animals (10 out of 13) from those scored in control chimeras that received syngeneic thymic anlagen. In all cases analyzed, such Mls-1a-reactive T cells could be stimulated at levels comparable to control responses, both in vitro and in vivo. The few cases in which Mls-1a reactive V beta TcR were reduced seem to reflect the variability in TcR V beta repertoires found in this experimental system. In contrast, BALB/c mice, injected at birth with DBA/2 spleen cells show a marked, albeit variable, reduction in the frequencies of V beta 6- and V beta 8.1-bearing CD4+ T cells, and lower frequencies of Mls-1a-reactive T cells in limiting dilution analyses. It appears, however, that V beta 6- and V beta 8.1-bearing T cells remaining in these mice are functionally competent. We conclude that Mls-1 antigens are not expressed by thymic epithelium.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0014-2980
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1397-404
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1534756-Animals,
pubmed-meshheading:1534756-Animals, Newborn,
pubmed-meshheading:1534756-Cell Death,
pubmed-meshheading:1534756-Cells, Cultured,
pubmed-meshheading:1534756-Chimera,
pubmed-meshheading:1534756-Epithelium,
pubmed-meshheading:1534756-Flow Cytometry,
pubmed-meshheading:1534756-Fluorescent Antibody Technique,
pubmed-meshheading:1534756-Immune Tolerance,
pubmed-meshheading:1534756-Immunosuppression,
pubmed-meshheading:1534756-Interleukin-2,
pubmed-meshheading:1534756-Mice,
pubmed-meshheading:1534756-Mice, Inbred Strains,
pubmed-meshheading:1534756-Mice, Nude,
pubmed-meshheading:1534756-Minor Lymphocyte Stimulatory Antigens,
pubmed-meshheading:1534756-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:1534756-T-Lymphocytes,
pubmed-meshheading:1534756-Thymus Gland
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Thymic epithelium induces neither clonal deletion nor anergy to Mls 1a antigens.
|
| pubmed:affiliation |
Unité d'Immunobiologie, Institut Pasteur, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|