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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-9-3
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pubmed:abstractText |
Anti-protective antigen (PA) immunoglobulin (Ig) G, toxin neutralization, and PA-specific IgG memory B cell responses were studied in patients with bioterrorism-related cutaneous or inhalation anthrax and in a patient with laboratory-acquired cutaneous anthrax. Responses were determined for >1 year after the onset of symptoms. Eleven days after the onset of symptoms (15 days after likely exposure), anti-PA IgG was detected in 16 of 17 patients with confirmed or suspected clinical anthrax who were tested. Anti-PA IgG remained detectable 8-16 months after the onset of symptoms in all 6 survivors of inhalation anthrax and in 7 of 11 survivors of cutaneous anthrax who were tested. Anti-PA IgG levels and serum toxin neutralizing activity were strongly associated (R2=0.83). PA-specific IgG memory B cells were detectable in all 6 survivors of inhalation anthrax but in only 2 of 7 patients with cutaneous anthrax who were tested. Anti-PA IgG is an important diagnostic marker of anthrax, a predictor of serum anti-toxin activity, and a marker of immunological memory against anthrax.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:AhmedRafiR,
pubmed-author:AubertRachael DRD,
pubmed-author:CrottyShaneS,
pubmed-author:DullPeter MPM,
pubmed-author:ElieCheryl MCM,
pubmed-author:FreemanAlison EAE,
pubmed-author:GlidewellJohnJ,
pubmed-author:GreeneCarolynC,
pubmed-author:LiHanH,
pubmed-author:MartinSandra KSK,
pubmed-author:PerkinsBradley ABA,
pubmed-author:QuinnConrad PCP,
pubmed-author:SchmidtDaniel SDS,
pubmed-author:SemenovaVeraV,
pubmed-author:StameyKaren LKL,
pubmed-author:StephensDavid SDS,
pubmed-author:Steward-ClarkEveleneE,
pubmed-author:StinsonKelly WallaceKW,
pubmed-author:TaylorThomas HTH
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1228-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15346332-Anthrax,
pubmed-meshheading:15346332-Antibodies, Bacterial,
pubmed-meshheading:15346332-Antigens, Bacterial,
pubmed-meshheading:15346332-B-Lymphocytes,
pubmed-meshheading:15346332-Bacterial Toxins,
pubmed-meshheading:15346332-Bioterrorism,
pubmed-meshheading:15346332-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15346332-Humans,
pubmed-meshheading:15346332-Immunoglobulin G,
pubmed-meshheading:15346332-Immunologic Memory,
pubmed-meshheading:15346332-Lung Diseases,
pubmed-meshheading:15346332-Neutralization Tests,
pubmed-meshheading:15346332-Skin Diseases
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pubmed:year |
2004
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pubmed:articleTitle |
Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax.
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pubmed:affiliation |
Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA. cquinn@cdc.gov.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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