Source:http://linkedlifedata.com/resource/pubmed/id/15345845
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 9
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| pubmed:dateCreated |
2004-9-3
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| pubmed:abstractText |
Three related compounds containing a pyrazole moiety with vicinal phenyl rings featuring a methylsulfonyl substituent are described, namely 3-methyl-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole, C17H16N2O2S, ethyl 1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole-3-carboxylate, C19H18N2O4S, and 1-[4-(methylsulfonyl)phenyl]-3-[3-(morpholino)phenoxymethyl]-5-phenyl-1H-pyrazole, C27H27N3O4S. The design of these compounds was based on celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, in order to study the influence of various substituents on COX-2 and 5-lipoxygenase (5-LOX) inhibition.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0108-2701
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
60
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
o648-52
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| pubmed:year |
2004
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| pubmed:articleTitle |
1-[4-(Methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole derivatives.
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| pubmed:affiliation |
Lab. Chimie Moléculaire Structurale, Facultés Universitaires N.-D. de la Paix, 61 Rue de Bruxelles, B-5000 Namur, Belgium. caroline.charlier@fundp.ac.be
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| pubmed:publicationType |
Journal Article
|