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rdf:type |
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lifeskim:mentions |
umls-concept:C0014257,
umls-concept:C0017262,
umls-concept:C0079281,
umls-concept:C0080194,
umls-concept:C0132555,
umls-concept:C0205113,
umls-concept:C0205263,
umls-concept:C0225336,
umls-concept:C0387583,
umls-concept:C0392756,
umls-concept:C0439581,
umls-concept:C1171318,
umls-concept:C1547530
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pubmed:issue |
11
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pubmed:dateCreated |
2004-11-5
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pubmed:abstractText |
Endothelium-derived vasoactive agents NO, endothelin-1 (ET-1), and prostacyclin (PGI2) not only regulate vascular tone but also influence atherogenic processes, including smooth muscle migration and proliferation, as well as monocyte and platelet adhesion. Complex hemodynamics characterized by the temporal phase angle between mechanical factors circumferential strain and wall shear stress (stress phase angle [SPA]) have been implicated in regions prone to pathologic development, such as atherosclerosis and intimal hyperplasia, in coronary and peripheral arteries where the mechanical forces are highly asynchronous (SPA=-180 degrees ). We determined the gene expression of endothelial NO synthase (eNOS), ET-1, and cyclooxygenase-2 (COX-2) affected by asynchronous hemodynamics (SPA=-180 degrees ) relative to normal hemodynamics (SPA=0 degrees ) in bovine aortic endothelial cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2088-94
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15345505-Animals,
pubmed-meshheading:15345505-Aorta,
pubmed-meshheading:15345505-Cattle,
pubmed-meshheading:15345505-Cell Culture Techniques,
pubmed-meshheading:15345505-Cells, Cultured,
pubmed-meshheading:15345505-Cyclooxygenase 2,
pubmed-meshheading:15345505-Endothelial Cells,
pubmed-meshheading:15345505-Endothelin-1,
pubmed-meshheading:15345505-Endothelium, Vascular,
pubmed-meshheading:15345505-Gene Expression Regulation,
pubmed-meshheading:15345505-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:15345505-Hemodynamics,
pubmed-meshheading:15345505-Nitric Oxide,
pubmed-meshheading:15345505-Nitric Oxide Synthase,
pubmed-meshheading:15345505-Nitric Oxide Synthase Type III,
pubmed-meshheading:15345505-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:15345505-Stress, Mechanical,
pubmed-meshheading:15345505-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Asynchronous shear stress and circumferential strain reduces endothelial NO synthase and cyclooxygenase-2 but induces endothelin-1 gene expression in endothelial cells.
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pubmed:affiliation |
Biomolecular Transport Dynamics Laboratory, Department of Bioengineering, The Pennsylvania State University, Fenske Lab, University Park, USA. dancu@engr.ccny.cuny.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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