Linked Life Data

15345344

Source:http://linkedlifedata.com/resource/pubmed/id/15345344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2004-9-3
pubmed:abstractText
In this study we compared a "baseline" condition of uncontrolled diesel engine exhaust (DEE) emissions generated with current (circa 2003) certification fuel to an emissions-reduction (ER) case with low sulfur fuel and a catalyzed particle trap. Lung toxicity assessments (resistance to respiratory viral infection, lung inflammation, and oxidative stress) were performed on mice (C57Bl/6) exposed by inhalation (6 hr/day for 7 days). The engine was operated identically (same engine load) in both cases, and the inhalation exposures were conducted at the same exhaust dilution rate. For baseline DEE, this dilution resulted in a particle mass (PM) concentration of approximately 200 microg/m3 PM, whereas the ER reduced the PM and almost every other measured constituent [except nitrogen oxides (NOx)] to near background levels in the exposure atmospheres. These measurements included PM, PM size distribution, PM composition (carbon, ions, elements), NOx, carbon monoxide, speciated/total volatile hydrocarbons, and several classes of semivolatile organic compounds. After exposure concluded, one group of mice was immediately sacrificed and assessed for inflammation and oxidative stress in lung homogenate. Another group of mice were intratracheally instilled with respiratory syncytial virus (RSV), and RSV lung clearance and inflammation was assessed 4 days later. Baseline DEE produced statistically significant biological effects for all measured parameters. The use of low sulfur fuel and a catalyzed trap either completely or nearly eliminated the effects.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-10788556, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-11401072, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-12028803, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-12091240, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-12134528, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-12441366, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-12676598, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-12797488, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-3183639, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-8679227, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-8899908, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-8943829, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-9072495, http://linkedlifedata.com/resource/pubmed/commentcorrection/15345344-9339225
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0091-6765
pubmed:author
pubmed:issnType
Print
pubmed:volume
112
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1307-12
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Effects of low sulfur fuel and a catalyzed particle trap on the composition and toxicity of diesel emissions.
pubmed:affiliation
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA. jmcdonal@lrri.org
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't