Linked Life Data

1534527

Source:http://linkedlifedata.com/resource/pubmed/id/1534527

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-7-6
pubmed:abstractText
At nonlethal doses, zymosan induces a systemic inflammatory state and promotes bacterial translocation. This study was performed to investigate the mechanisms by which zymosan causes intestinal mucosal injury and bacterial translocation. Bacterial translocation to the mesenteric lymph node was measured 24 hrs after intraperitoneal challenge with saline or zymosan (0.1 mg) in normal (CD-1), congenitally macrophage-hyporesponsive (C3H/HeJ), complement-deficient (DBA/2), or mast cell-deficient (W/Wv) mice. Since zymosan-induced bacterial translocation may be mediated by xanthine oxidase-generated oxidants, bacterial translocation was measured in mice pretreated with the xanthine oxidase inhibitor, allopurinol. To further investigate the role of oxidants in zymosan-induced bacterial translocation, ileal and hepatic levels of xanthine oxidase, myeloperoxidase, conjugated dienes, malondialdehyde, and the antioxidants--superoxide dismutase, catalase, and glutathione peroxidase, were measured.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0090-3493
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
782-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Zymosan-induced bacterial translocation: a study of mechanisms.
pubmed:affiliation
Department of Surgery, Louisiana State University Medical Center, Shreveport 71130-3932.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.