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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0033634,
umls-concept:C0039194,
umls-concept:C0086661,
umls-concept:C0162658,
umls-concept:C0185117,
umls-concept:C0442805,
umls-concept:C1314939,
umls-concept:C1705630,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2004-9-3
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pubmed:abstractText |
Cell growth during the G1 stage of the cell cycle is partly controlled by inducing c-myc expression, which in B cells is regulated by the NF-kappaB1 and c-Rel transcription factors. Here, we show that c-myc-dependent growth during T cell activation requires c-Rel and RelA and that blocking this growth by inhibiting protein kinase C theta (PKCtheta) coincides with a failure to upregulate c-myc due to impaired RelA nuclear import and inhibition of NFAT-dependent c-rel transcription. These results demonstrate that different Rel/NF-kappaB dimers regulate the mitogenic growth of mature T and B cells, with a signaling pathway incorporating PKCtheta and NFAT controlling c-Rel/RelA-induced c-myc expression in activated T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Myc protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NFATC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-rel,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-30
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15345217-Animals,
pubmed-meshheading:15345217-Cell Size,
pubmed-meshheading:15345217-DNA-Binding Proteins,
pubmed-meshheading:15345217-Lymphocyte Activation,
pubmed-meshheading:15345217-Mice,
pubmed-meshheading:15345217-Mitogens,
pubmed-meshheading:15345217-NF-kappa B,
pubmed-meshheading:15345217-NFATC Transcription Factors,
pubmed-meshheading:15345217-Nuclear Proteins,
pubmed-meshheading:15345217-Protein Kinase C,
pubmed-meshheading:15345217-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:15345217-Proto-Oncogene Proteins c-rel,
pubmed-meshheading:15345217-Signal Transduction,
pubmed-meshheading:15345217-T-Lymphocytes,
pubmed-meshheading:15345217-Transcription Factor RelA,
pubmed-meshheading:15345217-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappaB-dependent c-myc expression.
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pubmed:affiliation |
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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