Source:http://linkedlifedata.com/resource/pubmed/id/15344958
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-9-3
|
| pubmed:abstractText |
Thrombotic microangiopathy (TMA) has attracted attention as a complication of bone marrow transplantation (BMT). The association of Helicobacter pylori (H. pylori) with thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP/HUS) after BMT was studied. Among 74 consecutive patients undergoing transplantation, six developed TTP/HUS (the TTP/HUS group) and 68 did not (controls). These six patients were compared with the other 68 patients to investigate differences of the IL-12 and 8 levels, H. pylori and various clinical characteristics. The patients who developed TTP/HUS seemed not apparently different from those who did not in background characteristics, except that they had a significantly higher H. pylori-positive rate (p < 0.05). In the TTP/HUS group, however, the levels of interleukin-12 and interleukin-8 increased significantly during the leukocyte recovery after BMT and at the onset of TTP/HUS, respectively, to 45.8 +/- 57.6 pg/mL and 274.8 +/- 65.9 pg/mL (p < 0.05 for both), when compared with their levels of 5.0 pg/mL in the control group. Thus, H. pylori may play a role in the pathogenesis of TTP/HUS after BMT, with cytokines (interleukin-8 and interleukin-12) also being involved.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0902-0063
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
547-51
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15344958-Adolescent,
pubmed-meshheading:15344958-Adult,
pubmed-meshheading:15344958-Bone Marrow Transplantation,
pubmed-meshheading:15344958-Colony Count, Microbial,
pubmed-meshheading:15344958-Female,
pubmed-meshheading:15344958-Helicobacter Infections,
pubmed-meshheading:15344958-Helicobacter pylori,
pubmed-meshheading:15344958-Hemolytic-Uremic Syndrome,
pubmed-meshheading:15344958-Humans,
pubmed-meshheading:15344958-Interleukin-12,
pubmed-meshheading:15344958-Interleukin-8,
pubmed-meshheading:15344958-Leukocytes,
pubmed-meshheading:15344958-Male,
pubmed-meshheading:15344958-Middle Aged,
pubmed-meshheading:15344958-Purpura, Thrombotic Thrombocytopenic,
pubmed-meshheading:15344958-Retrospective Studies,
pubmed-meshheading:15344958-Risk Factors,
pubmed-meshheading:15344958-Transplantation Conditioning
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Association of Helicobacter pylori with thrombotic thrombocytopenic purpura and hemolytic uremic syndrome after bone marrow transplantation.
|
| pubmed:affiliation |
Division of Hematology and Oncology, Department of Internal Medicine, Department of Medicine, Hyogo College of Medicine, Hyogo, Japan. htakatsu@hyo-med.ac.jp
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|