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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-9-2
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pubmed:abstractText |
Porcine endogenous retrovirus (PERV) is a potential pathogen in clinical xenotransplantation; transmission of PERV in vivo has been suggested in murine xenotransplantation models. We analyzed the transmission of PERV to human cells in vivo using a model in which immunodeficient NOD/SCID transgenic mice were transplanted with porcine and human lymphohematopoietic tissues. Our results demonstrate, we believe for the first time, that human and pig cells can coexist long-term (up to 25 weeks) without direct PERV infection of human cells. Despite the transplantation of porcine cells that did not produce human-tropic PERV, human cells from the chimeric mice were frequently found to contain PERV sequences. However, this transmission was due to the pseudotyping of PERV-C (a virus without human tropism) by xenotropic murine leukemia virus, rather than to de novo generation of human-tropic PERV. Thus, pseudotyping might account for the PERV transmission previously observed in mice. The absence of direct human cell infection following long-term in vivo coexistence with large numbers of porcine cells provides encouragement regarding the potential safety of using pigs that do not produce human-tropic PERV as source animals for transplantation to humans.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-10455044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-10491030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-10910267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-10936401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-10993079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11045635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11087157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11170992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11202575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11257189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11263553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11349732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11680007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11861871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11890525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11967290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-11986242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-12107737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-12180842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-12388691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-12740431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-12795682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-137560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-14739221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-14963150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-193756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-4123693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9055854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9278321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9338777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9461178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9525633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9557749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9728985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9728986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9811736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15343388-9928206
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
695-700
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15343388-Amino Acid Sequence,
pubmed-meshheading:15343388-Animals,
pubmed-meshheading:15343388-Bone Marrow Transplantation,
pubmed-meshheading:15343388-Humans,
pubmed-meshheading:15343388-Liver Transplantation,
pubmed-meshheading:15343388-Mice,
pubmed-meshheading:15343388-Mice, Inbred NOD,
pubmed-meshheading:15343388-Mice, SCID,
pubmed-meshheading:15343388-Mice, Transgenic,
pubmed-meshheading:15343388-Molecular Sequence Data,
pubmed-meshheading:15343388-Retroviridae,
pubmed-meshheading:15343388-Retroviridae Infections,
pubmed-meshheading:15343388-Species Specificity,
pubmed-meshheading:15343388-Swine,
pubmed-meshheading:15343388-Thymus Gland,
pubmed-meshheading:15343388-Transplantation, Heterologous,
pubmed-meshheading:15343388-Transplantation Chimera,
pubmed-meshheading:15343388-Virus Replication
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pubmed:year |
2004
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pubmed:articleTitle |
Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice.
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pubmed:affiliation |
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. yongguang.yang@tbrc.mgh.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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