Source:http://linkedlifedata.com/resource/pubmed/id/15343347
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2004-9-28
|
| pubmed:abstractText |
Human blood dendritic cells (DC) comprise plasmacytoid DC (PDC) and myeloid DC (MDC), which both prime antitumor T-cell responses. We prospectively monitored blood DC in 30 chronic myeloid leukemia (CML) patients before and after imatinib mesylate therapy. We found a dramatic reduction in PDC and MDC prior treatment. This reduction was associated with high plasmatic vascular endothelial growth factor (VEGF), a central regulator of angiogenesis which also participates to tumor-associated immune deficiencies. Phenotypic analysis of DC revealed in some patients a deficient expression of BDCA-4/neuropilin-1 on PDC, a molecule involved in angiogenesis and DC-T-cell interactions. High VEGF correlated to an altered Th1/Th2 balance in vivo and shifted PDC-induced T-cell polarization towards Th2 in vitro. Upon imatinib treatment, plasmatic VEGF rapidly decreased and a normal BDCA-4 expression was restored. PDC and MDC increased but did not reach the levels observed in healthy individuals. We conclude that VEGF may be a key player in blood DC deficiency in CML and we show that imatinib inhibits VEGF overproduction. Incomplete recovery of blood DC under imatinib despite VEGF normalization suggests a negative impact of this drug on dendritopoiesis in vivo and may result in a sustained defect in DC-mediated anti-CML responses.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropilin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/blood dendritic cell antigen 4...,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0887-6924
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1656-61
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| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15343347-Adult,
pubmed-meshheading:15343347-Aged,
pubmed-meshheading:15343347-Antigens, Surface,
pubmed-meshheading:15343347-Antineoplastic Agents,
pubmed-meshheading:15343347-Blood Cells,
pubmed-meshheading:15343347-Dendritic Cells,
pubmed-meshheading:15343347-Female,
pubmed-meshheading:15343347-Humans,
pubmed-meshheading:15343347-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:15343347-Male,
pubmed-meshheading:15343347-Middle Aged,
pubmed-meshheading:15343347-Myeloid Cells,
pubmed-meshheading:15343347-Neuropilin-1,
pubmed-meshheading:15343347-Piperazines,
pubmed-meshheading:15343347-Prospective Studies,
pubmed-meshheading:15343347-Pyrimidines,
pubmed-meshheading:15343347-Th1 Cells,
pubmed-meshheading:15343347-Th2 Cells,
pubmed-meshheading:15343347-Vascular Endothelial Growth Factor A
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Defective blood dendritic cells in chronic myeloid leukemia correlate with high plasmatic VEGF and are not normalized by imatinib mesylate.
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| pubmed:affiliation |
Unité INSERM U396 d'Immunogénétique Humaine, Institut Universitaire d'Hématologie, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|