Source:http://linkedlifedata.com/resource/pubmed/id/15343265
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2004-10-26
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| pubmed:abstractText |
This study further defines genetic susceptibility to JIA in the region centromeric to HLA-DRB1. DNA from 234 Finnish JIA nuclear families and 639 elderly Finnish control individuals was genotyped for five functional SNPs within the TAP2 and TAP1 loci ( approximately 200 kb centromeric of HLA-DRB1). Subsets of the controls (186) and patients (145) that had been previously typed for HLA-DRB1 were also genotyped by sequence for the HLA-DPB1 locus. Case/control and transmission disequilibrium test (TDT) methods revealed an association with the DPB1(*)030101 allele for JIA (OR 2.3, 95% CI 1.5-3.5). Notably, a detailed haplotypic analysis of the TAP2/TAP1 loci and their interaction with the HLA-DPB1(*)030101 and DRB1(*)08 and (*)11 alleles showed a variety of over-represented and under-represented TAP2/TAP1 haplotypes not evident in the single marker analysis. The strongest effect was observed in the polyarticular RF negative JIA subgroup for the 2-2-1-2-1 TAP2/TAP1 haplotype (TAP2B and TAP1A alleles) which showed an independent effect from both DRB1(*)08 and (*)11 (P<0.000003) and DPB1(*)030101 (P=0.02). We have provided evidence that the extended haplotypes (including HLA-DRB1, TAP2/TAP1, and HLA-DPB1) of pauciarticular and polyarticular RF negative disease are distinct. This observation may have implications for functional etiological differences between the pauciarticular and polyarticular JIA patients.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DP Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DP beta-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DPB1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains,
http://linkedlifedata.com/resource/pubmed/chemical/TAP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TAP2 protein, human
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1466-4879
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
5
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
562-71
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15343265-ATP-Binding Cassette Transporters,
pubmed-meshheading:15343265-Aged,
pubmed-meshheading:15343265-Arthritis, Juvenile Rheumatoid,
pubmed-meshheading:15343265-Case-Control Studies,
pubmed-meshheading:15343265-Chi-Square Distribution,
pubmed-meshheading:15343265-Child,
pubmed-meshheading:15343265-Child, Preschool,
pubmed-meshheading:15343265-Confidence Intervals,
pubmed-meshheading:15343265-Female,
pubmed-meshheading:15343265-Finland,
pubmed-meshheading:15343265-HLA-DP Antigens,
pubmed-meshheading:15343265-HLA-DP beta-Chains,
pubmed-meshheading:15343265-HLA-DR Antigens,
pubmed-meshheading:15343265-HLA-DRB1 Chains,
pubmed-meshheading:15343265-Haplotypes,
pubmed-meshheading:15343265-Humans,
pubmed-meshheading:15343265-Major Histocompatibility Complex,
pubmed-meshheading:15343265-Male,
pubmed-meshheading:15343265-Odds Ratio
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| pubmed:year |
2004
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| pubmed:articleTitle |
HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC.
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| pubmed:affiliation |
Rowe Program in Human Genetics and Molecular Medicine, Department of Biological Chemistry, University of California, Davis 95616, USA. jarunstadler@ucdavis.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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