pubmed-article:15342392 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0813971 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0812380 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C1705691 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0600531 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0919524 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C1425353 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
pubmed-article:15342392 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
pubmed-article:15342392 | pubmed:issue | 17 | lld:pubmed |
pubmed-article:15342392 | pubmed:dateCreated | 2004-9-2 | lld:pubmed |
pubmed-article:15342392 | pubmed:abstractText | TEL2 is a member of the ETS family of transcription factors, which is highly similar to TEL1/ETV6. It binds to DNA via the ETS domain and interacts with itself or TEL1 via the pointed domain. The expression of TEL2 in normal and leukemic hematopoietic cells suggests a role in hematopoietic development. In this article, we describe the role of TEL2 in hematopoietic differentiation and cellular transformation. Quantitative reverse transcription-PCR showed that the expression of TEL2 mRNA was down-regulated during monocytic differentiation of U937 and HL60 induced by 1,25-(OH)2 vitamin D3 and 12-O-tetradecanoylphorbol 13-acetate, respectively. Overexpression of TEL2 in U937 cells inhibited differentiation induced by vitamin D3. In contrast, overexpression of a TEL2 mutant lacking either the pointed domain or a functional ETS domain induced both differentiation of U937 cells and inhibited their growth in vitro and in vivo. In addition, these mutants blocked TEL2-mediated transcriptional repression of a synthetic promoter containing TEL2 binding sites. These data suggest that dominant-negative inhibition of TEL2 might cause differentiation. Quantitative reverse transcription-PCR demonstrated that TEL2 is expressed at higher level in some primary human leukemia samples than in normal bone marrow. Furthermore, overexpression of TEL2 in NIH3T3-UCLA cells blocked the inhibitory effect of TEL1 on Ras-induced cellular transformation. These results suggest that TEL2 may play an important role in hematopoiesis and oncogenesis. | lld:pubmed |
pubmed-article:15342392 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15342392 | pubmed:language | eng | lld:pubmed |
pubmed-article:15342392 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15342392 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:15342392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15342392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15342392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15342392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15342392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15342392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15342392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:15342392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15342392 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:15342392 | pubmed:month | Sep | lld:pubmed |
pubmed-article:15342392 | pubmed:issn | 0008-5472 | lld:pubmed |
pubmed-article:15342392 | pubmed:author | pubmed-author:EllisJohnJ | lld:pubmed |
pubmed-article:15342392 | pubmed:author | pubmed-author:PotterMarkM | lld:pubmed |
pubmed-article:15342392 | pubmed:author | pubmed-author:KawagoeHiroyu... | lld:pubmed |
pubmed-article:15342392 | pubmed:author | pubmed-author:GrosveldGerar... | lld:pubmed |
pubmed-article:15342392 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:15342392 | pubmed:day | 1 | lld:pubmed |
pubmed-article:15342392 | pubmed:volume | 64 | lld:pubmed |
pubmed-article:15342392 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:15342392 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:15342392 | pubmed:pagination | 6091-100 | lld:pubmed |
pubmed-article:15342392 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:15342392 | pubmed:year | 2004 | lld:pubmed |
pubmed-article:15342392 | pubmed:articleTitle | TEL2, an ETS factor expressed in human leukemia, regulates monocytic differentiation of U937 Cells and blocks the inhibitory effect of TEL1 on ras-induced cellular transformation. | lld:pubmed |
pubmed-article:15342392 | pubmed:affiliation | Department of Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. | lld:pubmed |
pubmed-article:15342392 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:15342392 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:15342392 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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