Source:http://linkedlifedata.com/resource/pubmed/id/15342373
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
17
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pubmed:dateCreated |
2004-9-2
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pubmed:abstractText |
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma and exhibits aggressive and heterogeneous clinical behavior. To genetically characterize DLBCL, we established our own array-based comparative genomic hybridization and analyzed a total of 70 cases [26 CD-positive (CD5+) DLBCL and 44 CD5-negative (CD5-) DLBCL cases]. Regions of genomic aberrations observed in >20% of cases of both the CD5+ and CD5- groups were gains of 1q21-q31, 1q32, 3p25-q29, 5p13, 6p21-p25, 7p22-q31, 8q24, 11q23-q24, 12q13-q21, 16p13, 18, and X and losses of 1p36, 3p14, 6q14-q25, 6q27, 9p21, and 17p11-p13. Because CD5 expression marks a subgroup with poor prognosis, we subsequently analyzed genomic gains and losses of CD5+ DLBCL compared with those of CD5-. Although both groups showed similar genomic patterns of gains and losses, gains of 10p14-p15 and 19q13 and losses of 1q43-q44 and 8p23 were found to be characteristic of CD5+ DLBCL. By focusing on the gain of 13q21-q34 and loss of 1p34-p36, we were also able to identify prognostically distinct subgroups among CD5+ DLBCL cases. These results suggest that array-based comparative genomic hybridization analysis provides a platform of genomic aberrations of DLBCL both common and specific to clinically distinct subgroups.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:KameokaYoshihiroY,
pubmed-author:MatsuoKeitaroK,
pubmed-author:MorishimaYasuoY,
pubmed-author:NakamuraShigeoS,
pubmed-author:OkamotoMasatakaM,
pubmed-author:OtaAkinobuA,
pubmed-author:SetoMasaoM,
pubmed-author:SivasundaramKarnanK,
pubmed-author:SuguroMiyukiM,
pubmed-author:SuzukiRitsuroR,
pubmed-author:TagawaHiroyukiH,
pubmed-author:TsuzukiShinobuS,
pubmed-author:YamaguchiMotokoM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5948-55
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15342373-Antigens, CD5,
pubmed-meshheading:15342373-Cell Line, Tumor,
pubmed-meshheading:15342373-Chromosome Aberrations,
pubmed-meshheading:15342373-Female,
pubmed-meshheading:15342373-Gene Dosage,
pubmed-meshheading:15342373-Gene Expression Profiling,
pubmed-meshheading:15342373-Humans,
pubmed-meshheading:15342373-Lymphoma, B-Cell,
pubmed-meshheading:15342373-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:15342373-Male,
pubmed-meshheading:15342373-Middle Aged,
pubmed-meshheading:15342373-Nucleic Acid Hybridization,
pubmed-meshheading:15342373-Prognosis
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pubmed:year |
2004
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pubmed:articleTitle |
Genome-wide array-based comparative genomic hybridization of diffuse large B-cell lymphoma: comparison between CD5-positive and CD5-negative cases.
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pubmed:affiliation |
Division of Molecular Medicine, Aichi Cancer Center Research Institute, Aichi, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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