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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1992-6-23
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pubmed:abstractText |
Substantial increases in the concentrations of the excitotoxin and N-methyl-D-aspartate-receptor agonist quinolinic acid (QUIN) occur in human patients and non-human primates with inflammatory diseases. Such increases were postulated to be secondary to induction of indoleamine 2,3-dioxygenase in inflammatory cells, particularly macrophages, by interferon-gamma. To test this hypothesis, human peripheral-blood macrophages were incubated with L-[13C6]tryptophan in the absence or presence of interferon-gamma. [13C6]QUIN was quantified by gas chromatography and electron-capture negative-chemical-ionization mass spectrometry. [13C6]QUIN was detected in the incubation medium of both unstimulated and stimulated cultures. Exposure to interferon-gamma substantially increased the accumulation of [13C6]QUIN in a dose- and time-dependent manner. The QUIN concentrations achieved exceeded those reported in both cerebrospinal fluid and blood of patients and of non-human primates with inflammatory diseases. Macrophages stimulated with interferon-gamma may be an important source of accelerated L-tryptophan conversion into QUIN in inflammatory diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-1531156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-1535532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-1826418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-1830237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-1907934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-1963097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-2141357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-2148832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-2163238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-2524015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-2966643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-2975477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1534219-6849138
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
283 ( Pt 3)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
633-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
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pubmed:year |
1992
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pubmed:articleTitle |
Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid.
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pubmed:affiliation |
Section on Analytical Biochemistry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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