Linked Life Data

15342083

Source:http://linkedlifedata.com/resource/pubmed/id/15342083

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-9-2
pubmed:abstractText
Human toxicosis induced by consumption of foodstuffs contaminated with trichothecenes presents one common major symptom: a haematological perturbation manifesting principally as thrombocytopenia and leukopenia. The patients have rapidly progressing coagulation problems, and compromised resistance to infections. Consequently, they are subject to septicaemia and massive haemorrhages. In horses, cattle, poultry, cats, mice and guinea pigs, subacute and subchronic ingestion of trichothecenes causes a decrease of circulating blood cells frequently associated with bone marrow failure. The origins of haematological effects observed in Fusarium toxin intoxications have been elucidated using in vitro tests. Haematopoietic progenitors are the main target of trichothecenes. Deoxynivalenol (DON) is the least myelotoxic and T-2 the most. As circulating blood cells present a less important sensitivity to these toxins, haematological troubles observed in toxicosis are due to myelotoxicity of these toxins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0378-4274
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-81
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Haematotoxicity of trichothecenes.
pubmed:affiliation
Laboratory of Food Toxicology (EA), ESMISAB, West Brittany University, Technopole Brest-Iroise, 29280 Plouzané, France.
pubmed:publicationType
Journal Article, Review