rdf:type |
|
lifeskim:mentions |
umls-concept:C0007635,
umls-concept:C0019704,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0073243,
umls-concept:C0162326,
umls-concept:C0181090,
umls-concept:C0205101,
umls-concept:C0302614,
umls-concept:C0598312,
umls-concept:C1704419,
umls-concept:C1706050
|
pubmed:issue |
19
|
pubmed:dateCreated |
2004-9-2
|
pubmed:abstractText |
We examined the suppressive effect of HIV-1 RNA gene cleavage on HIV-1 expression, using the catalytic RNA subunit RNase P and the 3'-half tRNA(Try) [external guide sequence (EGS)] in cultured cells. HIV-1 expression was inhibited by the tRNA(met)-EGS-U5 and U6-EGS-U5 from the tRNA(met) and U6 promoters, respectively. There was no difference in the inhibitory effects on HIV-1 expression between the tRNA(met) and U6 promoters.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Guide,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Transfer,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Transfer, Met,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonuclease P
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0960-894X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
4
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
4941-4
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:15341956-Anti-HIV Agents,
pubmed-meshheading:15341956-Cells, Cultured,
pubmed-meshheading:15341956-HIV-1,
pubmed-meshheading:15341956-Promoter Regions, Genetic,
pubmed-meshheading:15341956-RNA, Guide,
pubmed-meshheading:15341956-RNA, Messenger,
pubmed-meshheading:15341956-RNA, Transfer,
pubmed-meshheading:15341956-RNA, Transfer, Met,
pubmed-meshheading:15341956-RNA, Viral,
pubmed-meshheading:15341956-Ribonuclease P,
pubmed-meshheading:15341956-Virus Replication
|
pubmed:year |
2004
|
pubmed:articleTitle |
Effective inhibition of HIV-1 replication in cultured cells by external guide sequences and ribonuclease P.
|
pubmed:affiliation |
Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|