Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2004-9-2
pubmed:abstractText
Numerous bacterial species inhabit the lumen of the human intestine. The epithelial cells that line the intestinal barrier are in direct contact with many of these species and have developed sophisticated strategies to prevent bacterial invasion of host tissue beyond simply providing a physical blockade. Intestinal epithelial cells (IECs) possess receptors that are capable of recognizing bacterial products, and engagement of these receptors results in the production and secretion of immunoregulatory proteins, such as cytokines and chemokines, which mobilize immune effector cells, including macrophages, dendritic cells, and neutrophils. In addition, IECs can produce various lipid-based eicosanoids that can contribute to the orchestration of the immune response. A better understanding of how the intestinal epithelium interacts with its microbial constituents may provide insight into strategies for treatment of enteric infections and inflammatory bowel disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1522-8037
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
355-61
pubmed:dateRevised
2008-5-7
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Intestinal epithelial defense systems protect against bacterial threats.
pubmed:affiliation
Mucosal Immunology Laboratory, Massachusetts General Hospital, CNY, 114 16th Street (114-3503), Charlestown, MA 02129, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review