Source:http://linkedlifedata.com/resource/pubmed/id/15341479
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
|
| pubmed:dateCreated |
2004-9-2
|
| pubmed:abstractText |
The highly potent, selective, and brain-penetrant metabotropic glutamate subtype 5 (mGlu5) receptor antagonists 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile (47) and 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile (48) are reported. Compound 47 is active in the rat fear-potentiated startle (FPS) model of anxiety with ED(50) = 5.4 mg/kg (po) when dosed acutely. In this model the anxiolytic effects of 47 rapidly tolerate on repeated dosing.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-2623
|
| pubmed:author |
pubmed-author:AndersonJeffreyJ,
pubmed-author:BrodkinJesseJ,
pubmed-author:ChungJaniceJ,
pubmed-author:CosfordNicholas D PND,
pubmed-author:HuangDehuaD,
pubmed-author:JiangXiaohuiX,
pubmed-author:KingChristopherC,
pubmed-author:MunozBenitoB,
pubmed-author:PrasitPetpiboonP,
pubmed-author:RoppeJeffreyJ,
pubmed-author:SmithNicholas DND,
pubmed-author:TehraniLidaL,
pubmed-author:VarneyMark AMA,
pubmed-author:WangBoweiB
|
| pubmed:issnType |
Print
|
| pubmed:day |
9
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4645-8
|
| pubmed:meshHeading | |
| pubmed:year |
2004
|
| pubmed:articleTitle |
Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.
|
| pubmed:publicationType |
Letter
|