Source:http://linkedlifedata.com/resource/pubmed/id/15340242
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2004-9-1
|
| pubmed:abstractText |
Sho-saiko-to, one of the most frequently prescribed Kampo medicines, is used clinically to treat chronic hepatitis and has shown confirmed clinical efficacy. The present study investigated whether Sho-saiko-to can suppress cytotoxicity and tumor necrosis factor (TNF)-alpha production in endotoxin-treated J774A.1 cells. Sho-saiko-to (10-20 microg/ml) did not affect the proliferation of J774A.1 cells, while a high concentration (50 microg/ml) of Sho-saiko-to induced a slight reduction in cell viability. Treatment with Sho-saiko-to (10-50 microg/ml) significantly inhibited endotoxin (10 microg/ml)-induced cytotoxicity in J774A.1 cells. In addition, Sho-saiko-to (20 microg/ml) suppressed TNF-alpha production by endotoxin (1 microg/ml)-activated J774A.1 cells. These findings suggest that the Kampo prescription Sho-saiko-to suppresses cytotoxicity or TNF-alpha production in macrophages treated with endotoxin and that it may be useful in improving septic shock symptoms. Sho-saiko-to may therefore protect against some of the various disturbances caused by endotoxins through its ability to inhibit TNF-alpha production in septic shock.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
0918-6158
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1468-70
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| pubmed:meshHeading |
pubmed-meshheading:15340242-Animals,
pubmed-meshheading:15340242-Cell Death,
pubmed-meshheading:15340242-Cell Line,
pubmed-meshheading:15340242-Drugs, Chinese Herbal,
pubmed-meshheading:15340242-Endotoxins,
pubmed-meshheading:15340242-Macrophages,
pubmed-meshheading:15340242-Medicine, Chinese Traditional,
pubmed-meshheading:15340242-Medicine, Kampo,
pubmed-meshheading:15340242-Mice,
pubmed-meshheading:15340242-Salmonella typhimurium,
pubmed-meshheading:15340242-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Preventive effects of a traditional Chinese medicine (Sho-saiko-to) on endotoxin-induced cytotoxicity and tumor necrosis factor-alpha production in J774A.1 Cells.
|
| pubmed:affiliation |
First Department of Hygienic Chemistry; Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. shuhei@tohoku-pharm.ac.jp
|
| pubmed:publicationType |
Journal Article
|