Linked Life Data

15338951

Source:http://linkedlifedata.com/resource/pubmed/id/15338951

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-9-1
pubmed:abstractText
The unique properties of microwave in situ heating offer unparalleled opportunities for medicinal chemists to accelerate lead optimization processes in early drug discovery. The technology is ideal for palladium-catalyzed alteration chemistry as it allows for complete control over reactions, with the use of non-inert conditions, providing high chemoselectivity and rapid feedback. To illustrate the advantages of this methodology, we describe our applications and approaches for the rapid synthesis of novel aspartyl protease inhibitors using dedicated microwave equipment. Biological results from chemical studies of the different side-chain positions of HIV-1 and malarial plasmepsin I and II protease inhibitors are summarized.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1367-6733
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
417-27
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Microwave-enhanced medicinal chemistry: a high-speed opportunity for convenient preparation of protease inhibitors.
pubmed:affiliation
Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, BMC, Uppsala University Box 574, SE-751 23, Uppsala, Sweden.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't