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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-6-12
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pubmed:abstractText |
Gene replacement by transformation, employing selective genetic recombination techniques, has been used to delete or disrupt the qa-x, qa-y and qa-1S genes of the qa gene cluster of Neurospora crassa. The growth characteristics of the strain carrying the deletion of the qa-y gene support earlier evidence that this gene encodes a quinic acid permease. The strain containing the deletion of the qa-1S gene (delta qa-1S) was examined with respect to quinic acid induction and carbon catabolite repression. The delta qa-1S strain exhibits constitutive expression of the qa genes supporting earlier evidence that the qa-1S gene codes for a repressor. Several of the qa genes continued to be expressed at high levels even in the presence of glucose in the delta qa-1S strain, which indicates that transcription of these genes is not being affected directly by a repressor molecule in the presence of glucose.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-137228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-159454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-16593723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-1825499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-2147126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-2201902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-2525625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-2549376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-2835177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-2931582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-2951591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-2961304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-2977301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-388424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-6198093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-6230518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-6322189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-6458044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1533844-922889
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:geneSymbol |
qa
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
729-36
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
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pubmed:year |
1992
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pubmed:articleTitle |
Use of gene replacement transformation to elucidate gene function in the qa gene cluster of Neurospora crassa.
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pubmed:affiliation |
Department of Genetics, University of Georgia, Athens 30602.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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