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rdf:type |
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lifeskim:mentions |
umls-concept:C0001927,
umls-concept:C0015840,
umls-concept:C0023546,
umls-concept:C0026473,
umls-concept:C0031327,
umls-concept:C0033268,
umls-concept:C0073076,
umls-concept:C0243192,
umls-concept:C0597357,
umls-concept:C1524059,
umls-concept:C1533691,
umls-concept:C1707455
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pubmed:issue |
7
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pubmed:dateCreated |
2004-8-31
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pubmed:abstractText |
Beta2-adrenergic receptor agonists have several effects on airway function, most of which are mediated in a variety of cell types resulting in increased c-AMP-production and inhibition of inflammatory mediator production. However, their stimulating effects on cAMP-production became known to be inversed by increasing phosphodiesterase (PDE) activity and degradation of cAMP. Therefore, in this study we have evaluated the efficacy of reproterol, a dual acting beta2-adrenoceptor agonist and PDE-inhibitor, as compared to salbutamol and fenoterol with respect to production of cAMP and LTB4 in cultured monocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-3-isobutylxanthine,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Albuterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Fenoterol,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene B4,
http://linkedlifedata.com/resource/pubmed/chemical/Metaproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2,
http://linkedlifedata.com/resource/pubmed/chemical/Theophylline,
http://linkedlifedata.com/resource/pubmed/chemical/reproterol
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0949-2321
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
365-70
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15337638-1-Methyl-3-isobutylxanthine,
pubmed-meshheading:15337638-Adrenergic beta-Agonists,
pubmed-meshheading:15337638-Adult,
pubmed-meshheading:15337638-Albuterol,
pubmed-meshheading:15337638-Cells, Cultured,
pubmed-meshheading:15337638-Cyclic AMP,
pubmed-meshheading:15337638-Dose-Response Relationship, Drug,
pubmed-meshheading:15337638-Drug Combinations,
pubmed-meshheading:15337638-Fenoterol,
pubmed-meshheading:15337638-Humans,
pubmed-meshheading:15337638-Leukotriene B4,
pubmed-meshheading:15337638-Metaproterenol,
pubmed-meshheading:15337638-Monocytes,
pubmed-meshheading:15337638-Phosphodiesterase Inhibitors,
pubmed-meshheading:15337638-Receptors, Adrenergic, beta-2,
pubmed-meshheading:15337638-Theophylline
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pubmed:year |
2004
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pubmed:articleTitle |
Different mechanisms of action of beta2-adrenergic receptor agonists: a comparison of reproterol, fenoterol and salbutamol on monocyte cyclic-AMP and leukotriene B4 production in vitro.
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pubmed:affiliation |
Department of Pneumology, Allergology and Sleep Medicine, Medical Outpatient Clinic, Bonn University Hospital, Germany. uwejuergens@t-online.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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