Source:http://linkedlifedata.com/resource/pubmed/id/15337184
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2004-8-31
|
| pubmed:abstractText |
We quantified telomerase activity (TA) in patients with oral and maxillofacial malignant and nonmalignant lesions, and compared it with their clinical status and grade of malignancy. Fifty-two malignant and 52 nonmalignant lesions were analyzed. All malignant lesions were pathologically diagnosed as oral squamous cell carcinoma (OSCC). Normal gingival tissue served as a control. These specimens were obtained by biopsy or surgical resection, and stored at -80 degrees C until use. TA was quantified by a fluorescence-based TRAP method. TA levels ranged from 0.00 to 95.24 (average 33.24)U/microgP in 52 malignant lesions, and from 0.00 to 79.35 (average 11.91)U/microgP in 52 nonmalignant lesions (P < 0.0001). TA was detected in 96.2% of malignant and 65.4% of nonmalignant lesions. There was no relationship between TA levels and clinical stages or YK classification. However, under WHO classification, there were significant differences (P < 0.05) between Grades I and III or II + III. Among nonmalignant lesions, epithelial dysplasia showed a significantly higher TA level than that of oral lichen planus (P < 0.05) and other benign lesions (P < 0.0001). Oral lichen planus also significantly differed from other benign lesions (P < 0.05). These results suggest that TA is related to the histological grade of malignancy, and is also useful as a prognostic predictor for precancerous lesions and conditions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Telomerase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0901-5027
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
693-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15337184-Acid Phosphatase,
pubmed-meshheading:15337184-Adolescent,
pubmed-meshheading:15337184-Adult,
pubmed-meshheading:15337184-Aged,
pubmed-meshheading:15337184-Aged, 80 and over,
pubmed-meshheading:15337184-Carcinoma, Squamous Cell,
pubmed-meshheading:15337184-Case-Control Studies,
pubmed-meshheading:15337184-Child,
pubmed-meshheading:15337184-Epithelium,
pubmed-meshheading:15337184-Female,
pubmed-meshheading:15337184-Humans,
pubmed-meshheading:15337184-Isoenzymes,
pubmed-meshheading:15337184-Lichen Planus, Oral,
pubmed-meshheading:15337184-Lymphatic Metastasis,
pubmed-meshheading:15337184-Male,
pubmed-meshheading:15337184-Middle Aged,
pubmed-meshheading:15337184-Mouth Neoplasms,
pubmed-meshheading:15337184-Neoplasm Staging,
pubmed-meshheading:15337184-Precancerous Conditions,
pubmed-meshheading:15337184-Telomerase,
pubmed-meshheading:15337184-Tumor Markers, Biological
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Clinical significance and usefulness of quantification of telomerase activity in oral malignant and nonmalignant lesions.
|
| pubmed:affiliation |
Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Niigata city, Niigata 951-8514, Japan. fujita1@dent.niigata-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|