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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-6-5
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pubmed:abstractText |
A novel cytokine receptor family has been defined based on structural homologies between the extracellular receptor domains. All receptors share a WSXWS consensus sequence just outside the plasma membrane. To evaluate whether this box of homology has a role in receptor function we synthesized peptides encompassed within the WSXWS region. In a basophil mediator release assay, three peptides inhibited the priming effect of interleukin (IL)-3, IL-5, and granulocyte/macrophage colony-stimulating factor (GM-CSF) on synthesis of leukotriene C4 induced by chemotactic peptides. The study suggests that, analogous to the RGD motif in adhesive proteins, the WSXWS motif serves as a recognition site for functional protein-protein interaction of cytokine receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/N-Formylmethionine...,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Colony-Stimulating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/SRS-A
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1056-5477
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1533539-Amino Acid Sequence,
pubmed-meshheading:1533539-Basophils,
pubmed-meshheading:1533539-Chromatography, High Pressure Liquid,
pubmed-meshheading:1533539-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:1533539-Humans,
pubmed-meshheading:1533539-Interleukin-3,
pubmed-meshheading:1533539-Interleukin-5,
pubmed-meshheading:1533539-Molecular Sequence Data,
pubmed-meshheading:1533539-N-Formylmethionine Leucyl-Phenylalanine,
pubmed-meshheading:1533539-Oligopeptides,
pubmed-meshheading:1533539-Receptors, Colony-Stimulating Factor,
pubmed-meshheading:1533539-Receptors, Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:1533539-Receptors, Immunologic,
pubmed-meshheading:1533539-Receptors, Interleukin,
pubmed-meshheading:1533539-Receptors, Interleukin-3,
pubmed-meshheading:1533539-Receptors, Interleukin-5,
pubmed-meshheading:1533539-SRS-A
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pubmed:year |
1992
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pubmed:articleTitle |
Peptide analogues of consensus receptor sequence inhibit the action of cytokines on human basophils.
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pubmed:affiliation |
Institute of Clinical Immunology, Inselspital, Bern, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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