Linked Life Data

15333728

Source:http://linkedlifedata.com/resource/pubmed/id/15333728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2004-8-30
pubmed:abstractText
The mycotoxin ochratoxin A (OA) is a cause of endemic nephropathy in farm animals and humans. Reabsorption of OA along the nephron results from nonionic diffusion and by carrier-mediated mechanisms, indicating that urine alkalinization may help to accelerate OA excretion and thus reduce its toxicity. The aim of the present study was to investigate the effect of a dietary sodium bicarbonate supplementation as a means of increasing urinary pH on the systemic availability and excretion of OA in pigs. Dietary supplementation of 2% sodium bicarbonate significantly increased urinary pH (5.7 +/- 0.2 to 8.3 +/- 0.1) and daily urine volume (1108 +/- 276 to 2479 +/- 912 mL). The systemic availability of OA and its dechloro-analog, Ochratoxin B (OB), calculated as the area under the curve (AUC) was reduced to 75 and 68%, respectively, of the control group (P < 0.05). This effect was due mainly to an accelerated elimination of OA and OB in the urine. The faster renal elimination may be due to reduced reabsorption of the ochratoxins by nonionic diffusion, and other H(+)-dependent mechanisms. Thus, urinary alkalinization may be an efficient means to partially reduce the toxic effects of OA in pigs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2355-8
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Alkalinization of urinary pH accelerates renal excretion of ochratoxin A in pigs.
pubmed:affiliation
Institute of Animal Nutrition, Physiology, and Metabolism, Christian-Albrechts-University Kiel, 24098 Kiel, Germany. blank@aninut.uni-kiel.de
pubmed:publicationType
Journal Article