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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2004-8-27
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pubmed:abstractText |
Several primate models indicate that cytotoxic T lymphocyte-inducing vaccines may be unable to prevent human immunodeficiency virus infection but may have a long-term benefit in controlling viral replication and delaying disease progression. Here we show that analysis of the kinetics of antigen-specific CD8+ T-cell expansion suggests a delay in activation following infection that allows unimpeded early viral replication. Viral kinetics do not differ between controls and vaccinees during this delay phase. An increase in virus-specific CD8+ T-cell numbers around day 10 postinfection coincides with a slowing in viral replication in vaccinees and reduces peak viral loads by around 1 log. However, this response is too little too late to prevent establishment of persistent infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-10075982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-10233944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-10449771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-10499922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-10577640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-10837069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-10880527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-10906202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-10973282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11014195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11039923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11313426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11393868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11602708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11689887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11696593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11748275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11797011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11797012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-11984594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12001999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12021371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12072518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12244170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12414983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12574347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12574372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12594955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12663797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12663814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12690201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12690202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12759421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-12941922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-14645590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-1721107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-7516038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-7585062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-8057491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-8096155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-8207839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-8633023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-8638160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-8875941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9012837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9144289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9310470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9311831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9345075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9565631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9655482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9847402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9930870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9933110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15331742-9933172
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 American Society for Microbiology
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10096-103
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15331742-Humans,
pubmed-meshheading:15331742-Animals,
pubmed-meshheading:15331742-Kinetics,
pubmed-meshheading:15331742-Time Factors,
pubmed-meshheading:15331742-Macaca mulatta,
pubmed-meshheading:15331742-Virus Replication,
pubmed-meshheading:15331742-Gene Products, gag,
pubmed-meshheading:15331742-HIV-1,
pubmed-meshheading:15331742-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:15331742-Simian immunodeficiency virus
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