Source:http://linkedlifedata.com/resource/pubmed/id/15331579
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2004-11-16
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pubmed:abstractText |
The RET gene encodes a single-pass transmembrane receptor tyrosine kinase. RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. The latter may arise as a component of multiple endocrine neoplasia type 2 syndromes; germline mutations in RET are responsible for multiple endocrine neoplasia type 2 inheritance. In this report we review data on the mechanisms leading to RET oncogenic conversion and on RET targeting as a strategy in thyroid cancer treatment.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ret,
http://linkedlifedata.com/resource/pubmed/chemical/RET protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0013-7227
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5448-51
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15331579-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15331579-Humans,
pubmed-meshheading:15331579-Oncogene Proteins,
pubmed-meshheading:15331579-Proto-Oncogene Proteins c-ret,
pubmed-meshheading:15331579-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:15331579-Thyroid Neoplasms
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pubmed:year |
2004
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pubmed:articleTitle |
Minireview: RET: normal and abnormal functions.
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pubmed:affiliation |
Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c/o Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Naples, Italy. masantor@unina.it
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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