Source:http://linkedlifedata.com/resource/pubmed/id/15331538
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2004-8-27
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| pubmed:abstractText |
To evaluate the effects of kidney-pancreas transplantation on hemostatic abnormalities in uremic type 1 diabetic patients, we conducted a cross-sectional study involving 12 type 1 diabetic patients, 30 uremic type 1 diabetic patients, 27 uremic type 1 diabetic patients who had a kidney-pancreas transplant, 12 uremic type 1 diabetic patients who had a kidney-alone transplant, and 13 healthy control subjects. We evaluated platelet and clotting system. Platelets in the group of uremic type 1 diabetic patients were significantly larger than platelets in the other groups. Resting calcium levels were significantly higher in the uremic type 1 diabetic patients and uremic type 1 diabetic patients who had a kidney-alone transplant than in the type 1 diabetic patients who had a kidney-pancreas transplant and control subjects. CD41 expression was significantly reduced in platelets from the uremic type 1 diabetic patients compared with the other groups. Levels of hypercoagulability markers in the type 1 diabetic patients who had a kidney-pancreas transplant and, to a lesser extent, the uremic type 1 diabetic patients who had a kidney-alone transplant but not the uremic type 1 diabetic patients were similar to those of the control subjects. A reduction in natural anticoagulants was evident in the uremic type 1 diabetic patients, whereas near-normal values were observed in the type 1 diabetic patients who had a kidney-pancreas transplant and uremic type 1 diabetic patients who had a kidney-alone transplant. Hemostatic abnormalities were not observed in type 1 diabetic patients who had a kidney-pancreas transplant. This finding might explain the lower cardiovascular death rate observed in type 1 diabetic patients who had a kidney-pancreas transplant compared with uremic type 1 diabetic patients who had a kidney-alone transplant or uremic type 1 diabetic patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoprotein IIb,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, PAR-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/protease-activated receptor 3
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0012-1797
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| pubmed:author |
pubmed-author:BelloniDanielaD,
pubmed-author:BifariFrancescoF,
pubmed-author:CapellaCarloC,
pubmed-author:D'AngeloArmandoA,
pubmed-author:Della VallePatriziaP,
pubmed-author:FedeliCarloC,
pubmed-author:FerreroElisabettaE,
pubmed-author:FinziGiovannaG,
pubmed-author:FiorinaPaoloP,
pubmed-author:FolliFrancoF,
pubmed-author:GuzziValeriaV,
pubmed-author:PellegattaFabioF,
pubmed-author:PlacidiClaudiaC,
pubmed-author:SecchiAntonioA,
pubmed-author:UselliniLucianaL
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| pubmed:issnType |
Print
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| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2291-300
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15331538-Adult,
pubmed-meshheading:15331538-Blood Coagulation,
pubmed-meshheading:15331538-Blood Coagulation Disorders,
pubmed-meshheading:15331538-Blood Platelets,
pubmed-meshheading:15331538-Calcium,
pubmed-meshheading:15331538-Cross-Sectional Studies,
pubmed-meshheading:15331538-Diabetes Mellitus, Type 1,
pubmed-meshheading:15331538-Diabetic Nephropathies,
pubmed-meshheading:15331538-Female,
pubmed-meshheading:15331538-Humans,
pubmed-meshheading:15331538-Kidney Transplantation,
pubmed-meshheading:15331538-Male,
pubmed-meshheading:15331538-Middle Aged,
pubmed-meshheading:15331538-Pancreas Transplantation,
pubmed-meshheading:15331538-Partial Thromboplastin Time,
pubmed-meshheading:15331538-Platelet Membrane Glycoprotein IIb,
pubmed-meshheading:15331538-Prothrombin Time,
pubmed-meshheading:15331538-Receptor, PAR-1,
pubmed-meshheading:15331538-Receptors, Thrombin,
pubmed-meshheading:15331538-Signal Transduction,
pubmed-meshheading:15331538-Uremia
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| pubmed:year |
2004
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| pubmed:articleTitle |
Normalization of multiple hemostatic abnormalities in uremic type 1 diabetic patients after kidney-pancreas transplantation.
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| pubmed:affiliation |
Internal Medicine, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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