Source:http://linkedlifedata.com/resource/pubmed/id/15331532
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2004-8-27
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| pubmed:abstractText |
Interleukin-6 (IL-6) could be a possible mediator of insulin resistance. We investigated whether IL-6 could inhibit insulin signaling in human skeletal myotubes and whether suppressor of cytokine signaling 3 (SOCS-3) could be related to insulin resistance in vivo in humans. IL-6 inhibited insulin signaling and induced SOCS-3 expression in differentiated myotubes. SOCS-3 mRNA levels were significantly increased in the skeletal muscle of type 2 diabetic patients compared with control subjects and correlated with reduced insulin-stimulated glucose uptake. In contrast, SOCS-3 mRNA levels were reduced in muscle of obese nondiabetic subjects compared with type 2 diabetic patients, despite similar circulating concentrations of IL-6. Increased SOCS-3 mRNA levels in diabetes were not attributable to hyperglycemia, as type 1 diabetic patients had normal SOCS-3 mRNA expression in muscle. However, the combination of high glucose and IL-6 levels in type 2 diabetic patients may induce SOCS-3 expression, as has been seen in human muscle cells. In subcutaneous adipose tissue, SOCS-3 mRNA levels were increased in obese individuals and strongly correlated with IL-6 expression, supporting a paracrine effect of IL-6 on SOCS-3 expression in fat. Taken together, our results showed that SOCS-3 expression in human skeletal muscle in vivo is not related to insulin resistance in the presence of elevated IL-6 concentrations and suggest that cytokine action could differ in type 2 diabetic patients and nondiabetic obese subjects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SOCS3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0012-1797
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
53
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2232-41
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15331532-Adipose Tissue,
pubmed-meshheading:15331532-Adult,
pubmed-meshheading:15331532-Cells, Cultured,
pubmed-meshheading:15331532-Diabetes Mellitus,
pubmed-meshheading:15331532-Diabetes Mellitus, Type 2,
pubmed-meshheading:15331532-Female,
pubmed-meshheading:15331532-Gene Expression,
pubmed-meshheading:15331532-Humans,
pubmed-meshheading:15331532-Hyperglycemia,
pubmed-meshheading:15331532-Insulin,
pubmed-meshheading:15331532-Insulin Resistance,
pubmed-meshheading:15331532-Interleukin-6,
pubmed-meshheading:15331532-Male,
pubmed-meshheading:15331532-Middle Aged,
pubmed-meshheading:15331532-Muscle, Skeletal,
pubmed-meshheading:15331532-Muscle Fibers, Skeletal,
pubmed-meshheading:15331532-Obesity,
pubmed-meshheading:15331532-RNA, Messenger,
pubmed-meshheading:15331532-Repressor Proteins,
pubmed-meshheading:15331532-Signal Transduction,
pubmed-meshheading:15331532-Suppressor of Cytokine Signaling Proteins,
pubmed-meshheading:15331532-Transcription Factors
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| pubmed:year |
2004
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| pubmed:articleTitle |
Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients.
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| pubmed:affiliation |
INSERM U449/INRA U1235, Faculté de Médecine René Laennec, Rue G. Paradin, F-69372 Lyon, Cedex 08, France. jennifer.rieusset@univ-lyon1.fr
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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