|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2004-8-27
|
|
pubmed:abstractText |
Familial pancreatic cancer (FPC) (approximately 3% of all cases) has not been linked to defects in any specific gene. Germline inactivation of the gene LKB1/STK11 have been shown to cause Peutz-Jeghers syndrome (PJS) associated with a approximately 100-fold higher risk for the development of pancreatic cancer. We have analysed 39 index patients from European FPC families for mutations of LKB1/STK11 by sequencing of their DNA. No germline mutation was found within the complete coding region. Therefore, our results indicate that LKB1/STK11 is not altered in the germline of patients with hereditary pancreatic cancer.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0304-3835
|
|
pubmed:author |
pubmed-author:BartschDetlef KDK,
pubmed-author:GrützmannRobertR,
pubmed-author:GreenhalfWilliamW,
pubmed-author:KochRainerR,
pubmed-author:McCarthyEmmaE,
pubmed-author:McFaulChristopherC,
pubmed-author:NeoptolemosJohn PJP,
pubmed-author:PilarskyChristianC,
pubmed-author:RiederHaraldH,
pubmed-author:SaegerHans DetlevHD,
pubmed-author:Sina-FreyMercedesM
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
214
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
63-8
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15331174-Adult,
pubmed-meshheading:15331174-Aged,
pubmed-meshheading:15331174-Carcinoma,
pubmed-meshheading:15331174-DNA Mutational Analysis,
pubmed-meshheading:15331174-Female,
pubmed-meshheading:15331174-Genetic Predisposition to Disease,
pubmed-meshheading:15331174-Germ-Line Mutation,
pubmed-meshheading:15331174-Humans,
pubmed-meshheading:15331174-Male,
pubmed-meshheading:15331174-Middle Aged,
pubmed-meshheading:15331174-Pancreatic Neoplasms,
pubmed-meshheading:15331174-Pedigree,
pubmed-meshheading:15331174-Protein-Serine-Threonine Kinases
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma.
|
|
pubmed:affiliation |
Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
