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pubmed-article:15329905pubmed:abstractTextIn 1994, the Eastern Cooperative Oncology Group (ECOG) initiated for the Breast Intergroup a randomized clinical trial (E3193) in premenopausal patients with early-stage breast carcinoma (lymph node-negative and receptor-positive, with tumors measuring < or = 3 cm) comparing tamoxifen as adjuvant systemic therapy with tamoxifen and ovarian ablation by one of three different methods. Ovarian ablation could be accomplished either via radiotherapy (RT) (20 Gray [Gy]/10 fractions to a modified pelvic volume), surgical oophorectomy, or goserelin/leuprolide injections as per patient/physician choice. In the current study, we report the efficacy of pelvic RT with this dose-fractionation scheme in the induction of ovarian ablation.lld:pubmed
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pubmed-article:15329905pubmed:copyrightInfoCopyright 2004 American Cancer Society.lld:pubmed
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pubmed-article:15329905pubmed:articleTitleEfficacy of radiotherapy for ovarian ablation: results of a breast intergroup study.lld:pubmed
pubmed-article:15329905pubmed:affiliationDepartment of Radiation Oncology, WellStar Kennestone Hospital, Marietta, GA 30060, USA. LHughesmd@aol.comlld:pubmed
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