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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2004-8-26
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pubmed:abstractText |
In 1994, the Eastern Cooperative Oncology Group (ECOG) initiated for the Breast Intergroup a randomized clinical trial (E3193) in premenopausal patients with early-stage breast carcinoma (lymph node-negative and receptor-positive, with tumors measuring < or = 3 cm) comparing tamoxifen as adjuvant systemic therapy with tamoxifen and ovarian ablation by one of three different methods. Ovarian ablation could be accomplished either via radiotherapy (RT) (20 Gray [Gy]/10 fractions to a modified pelvic volume), surgical oophorectomy, or goserelin/leuprolide injections as per patient/physician choice. In the current study, we report the efficacy of pelvic RT with this dose-fractionation scheme in the induction of ovarian ablation.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-543X
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pubmed:author |
pubmed-author:Cancer and Leukemia Group B,
pubmed-author:Eastern Cooperative Oncology Group,
pubmed-author:GrayRobert JRJ,
pubmed-author:HughesLorie LLL,
pubmed-author:IngleJames NJN,
pubmed-author:MartinoSilvanaS,
pubmed-author:North Central Cancer Treatment Group,
pubmed-author:RobertNicholas JNJ,
pubmed-author:SolinLawrence JLJ,
pubmed-author:Southwest Oncology Group,
pubmed-author:TripathyDebuD,
pubmed-author:WoodWilliam CWC
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pubmed:copyrightInfo |
Copyright 2004 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
969-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15329905-Adult,
pubmed-meshheading:15329905-Antineoplastic Agents, Hormonal,
pubmed-meshheading:15329905-Breast Neoplasms,
pubmed-meshheading:15329905-Combined Modality Therapy,
pubmed-meshheading:15329905-Female,
pubmed-meshheading:15329905-Humans,
pubmed-meshheading:15329905-Middle Aged,
pubmed-meshheading:15329905-Ovariectomy,
pubmed-meshheading:15329905-Premenopause,
pubmed-meshheading:15329905-Tamoxifen,
pubmed-meshheading:15329905-Treatment Outcome
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pubmed:year |
2004
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pubmed:articleTitle |
Efficacy of radiotherapy for ovarian ablation: results of a breast intergroup study.
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pubmed:affiliation |
Department of Radiation Oncology, WellStar Kennestone Hospital, Marietta, GA 30060, USA. LHughesmd@aol.com
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial
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