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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-8-26
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pubmed:abstractText |
Nonsyndromic cleft lip with or without cleft palate, CL(P), is a common human birth defect with a complex unknown genetic cause. The mouse model is the "A/-" strains. Our previous studies mapped two loci: clf1 on Chr11 and clf2 on Chr13--with a strong genetic maternal effect on the level of risk. Here we test the hypothesis that CL(P) is digenic and identify candidate genes for clf1 and clf2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1542-0752
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
509-18
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15329828-Animals,
pubmed-meshheading:15329828-Base Sequence,
pubmed-meshheading:15329828-Chromosome Mapping,
pubmed-meshheading:15329828-Cleft Lip,
pubmed-meshheading:15329828-Crosses, Genetic,
pubmed-meshheading:15329828-DNA Primers,
pubmed-meshheading:15329828-Disease Models, Animal,
pubmed-meshheading:15329828-Female,
pubmed-meshheading:15329828-Male,
pubmed-meshheading:15329828-Mice,
pubmed-meshheading:15329828-Mice, Inbred A,
pubmed-meshheading:15329828-Mice, Inbred C57BL,
pubmed-meshheading:15329828-Polymerase Chain Reaction,
pubmed-meshheading:15329828-Polymorphism, Genetic
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pubmed:year |
2004
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pubmed:articleTitle |
A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci.
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pubmed:affiliation |
Department of Medical Genetics, University of British Columbia, Vancouver, British ColumbiaV6T 1Z3, Canada. juriloff@interchange.ubc.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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