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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-8-26
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pubmed:abstractText |
The majority of surgical patients receive inhaled anesthetics, principally small haloalkanes and haloethers. Long-term cognitive problems occur in the elderly subsequent to anesthesia and surgery, and previous surgery might also be a risk factor for neurodegenerative disorders like Alzheimer and Parkinson disease. The authors hypothesize that inhaled anesthetics contribute to these effects through a durable enhancement of peptide oligomerization.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Depressants,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Halothane,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflurane,
http://linkedlifedata.com/resource/pubmed/chemical/L-Lactate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Propofol
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
703-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15329595-Adrenal Gland Neoplasms,
pubmed-meshheading:15329595-Amyloid beta-Peptides,
pubmed-meshheading:15329595-Anesthetics, Inhalation,
pubmed-meshheading:15329595-Animals,
pubmed-meshheading:15329595-Central Nervous System Depressants,
pubmed-meshheading:15329595-Chromatography, Gel,
pubmed-meshheading:15329595-Ethanol,
pubmed-meshheading:15329595-Fluorescent Dyes,
pubmed-meshheading:15329595-Halothane,
pubmed-meshheading:15329595-Image Processing, Computer-Assisted,
pubmed-meshheading:15329595-Isoflurane,
pubmed-meshheading:15329595-Kinetics,
pubmed-meshheading:15329595-L-Lactate Dehydrogenase,
pubmed-meshheading:15329595-Microscopy, Electron,
pubmed-meshheading:15329595-Oligopeptides,
pubmed-meshheading:15329595-Pheochromocytoma,
pubmed-meshheading:15329595-Propofol,
pubmed-meshheading:15329595-Rats,
pubmed-meshheading:15329595-Tumor Cells, Cultured
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pubmed:year |
2004
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pubmed:articleTitle |
Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity.
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pubmed:affiliation |
Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania 19104-4283, USA. roderic.eckenhoff@uphs.upenn.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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