| pubmed-article:15328154 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15328154 | lifeskim:mentions | umls-concept:C1337103 | lld:lifeskim |
| pubmed-article:15328154 | lifeskim:mentions | umls-concept:C1705388 | lld:lifeskim |
| pubmed-article:15328154 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:15328154 | lifeskim:mentions | umls-concept:C0007613 | lld:lifeskim |
| pubmed-article:15328154 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15328154 | lifeskim:mentions | umls-concept:C1334309 | lld:lifeskim |
| pubmed-article:15328154 | lifeskim:mentions | umls-concept:C1425775 | lld:lifeskim |
| pubmed-article:15328154 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15328154 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15328154 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15328154 | pubmed:dateCreated | 2004-12-21 | lld:pubmed |
| pubmed-article:15328154 | pubmed:abstractText | Interaction of the activating ligand H60 with NKG2D receptor constitutes a major stimulatory pathway for natural killer (NK) cells. The influence of inhibitory Ly49 receptors on NKG2D-mediated activation is not clearly understood. Here we show that the magnitude of NKG2D-mediated cytotoxicity is directly proportional to both the levels of H60 and the nature of major histocompatibility complex (MHC) class I molecules expressed on the target cells. The expression levels of H60 on the target cells determined the extent to which the inhibition by Ly49C/I receptors can be overridden. In contrast, even a higher expression of H60 molecule on the target cells failed to overcome the inhibition mediated by Ly49A/G receptors. Also, the level of interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) generated by NK cells through anti-NKG2D monoclonal antibody (mAb)-mediated activation is significantly reduced by the presence of immobilized anti-Ly49A/G mAbs. Thus, NKG2D-mediated cytotoxicity and cytokine secretion results from the fine balance between activating and inhibitory receptors, thereby defining the NK cell-mediated immune responses. | lld:pubmed |
| pubmed-article:15328154 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15328154 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15328154 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15328154 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15328154 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:15328154 | pubmed:author | pubmed-author:ChenYuhongY | lld:pubmed |
| pubmed-article:15328154 | pubmed:author | pubmed-author:MalarkannanSu... | lld:pubmed |
| pubmed-article:15328154 | pubmed:author | pubmed-author:WangDeminD | lld:pubmed |
| pubmed-article:15328154 | pubmed:author | pubmed-author:RegunathanJey... | lld:pubmed |
| pubmed-article:15328154 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15328154 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15328154 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:15328154 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15328154 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15328154 | pubmed:pagination | 233-40 | lld:pubmed |
| pubmed-article:15328154 | pubmed:dateRevised | 2011-9-22 | lld:pubmed |
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| pubmed-article:15328154 | pubmed:meshHeading | pubmed-meshheading:15328154... | lld:pubmed |
| pubmed-article:15328154 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15328154 | pubmed:articleTitle | NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. | lld:pubmed |
| pubmed-article:15328154 | pubmed:affiliation | Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee 53226, USA. | lld:pubmed |
| pubmed-article:15328154 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15328154 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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