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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-12-21
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pubmed:abstractText |
Interaction of the activating ligand H60 with NKG2D receptor constitutes a major stimulatory pathway for natural killer (NK) cells. The influence of inhibitory Ly49 receptors on NKG2D-mediated activation is not clearly understood. Here we show that the magnitude of NKG2D-mediated cytotoxicity is directly proportional to both the levels of H60 and the nature of major histocompatibility complex (MHC) class I molecules expressed on the target cells. The expression levels of H60 on the target cells determined the extent to which the inhibition by Ly49C/I receptors can be overridden. In contrast, even a higher expression of H60 molecule on the target cells failed to overcome the inhibition mediated by Ly49A/G receptors. Also, the level of interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) generated by NK cells through anti-NKG2D monoclonal antibody (mAb)-mediated activation is significantly reduced by the presence of immobilized anti-Ly49A/G mAbs. Thus, NKG2D-mediated cytotoxicity and cytokine secretion results from the fine balance between activating and inhibitory receptors, thereby defining the NK cell-mediated immune responses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/KLRK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Klra1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Klra3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Klrk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Minor Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, NK Cell Lectin-Like,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell,
http://linkedlifedata.com/resource/pubmed/chemical/histocompatibility antigen H-2D(b),
http://linkedlifedata.com/resource/pubmed/chemical/minor H antigen H60
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-40
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pubmed:dateRevised |
2011-9-22
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pubmed:meshHeading |
pubmed-meshheading:15328154-Active Transport, Cell Nucleus,
pubmed-meshheading:15328154-Animals,
pubmed-meshheading:15328154-Antibodies, Monoclonal,
pubmed-meshheading:15328154-Antigens, Ly,
pubmed-meshheading:15328154-Cell Nucleus,
pubmed-meshheading:15328154-Cells, Cultured,
pubmed-meshheading:15328154-Cytotoxicity, Immunologic,
pubmed-meshheading:15328154-Down-Regulation,
pubmed-meshheading:15328154-H-2 Antigens,
pubmed-meshheading:15328154-Humans,
pubmed-meshheading:15328154-Killer Cells, Natural,
pubmed-meshheading:15328154-Lectins, C-Type,
pubmed-meshheading:15328154-Ligands,
pubmed-meshheading:15328154-Mice,
pubmed-meshheading:15328154-Minor Histocompatibility Antigens,
pubmed-meshheading:15328154-NF-kappa B,
pubmed-meshheading:15328154-NK Cell Lectin-Like Receptor Subfamily A,
pubmed-meshheading:15328154-NK Cell Lectin-Like Receptor Subfamily K,
pubmed-meshheading:15328154-Receptors, Immunologic,
pubmed-meshheading:15328154-Receptors, NK Cell Lectin-Like,
pubmed-meshheading:15328154-Receptors, Natural Killer Cell,
pubmed-meshheading:15328154-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors.
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pubmed:affiliation |
Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee 53226, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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