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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2004-8-25
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pubmed:abstractText |
The aim of this study was to determine whether there is an association between serum resistance, O serotypes, and the production of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae. Ninety ESBL-producing and 178 non-ESBL-producing K. pneumoniae isolates gathered in five European countries were O serotyped and tested for sensitivity to the serum's bactericidal effect. The frequency of serum-resistant isolates was higher among ESBL-producing strains (30%; 27/90 isolates) than among non-ESBL-producing strains (17.9%; 32/178 isolates) (P = 0.037; odds ratio [OR] = 1.96; 95% confidence interval [95% CI] = 1.08 to 3.53). Although O1 was the most common O serotype in both Klebsiella groups, its frequency among ESBL-producing strains was significantly higher (59%; 53/90 isolates) than among non-ESBL producers (36%; 64/178 isolates) (P = 0.0006; OR = 2.5; 95% CI = 1.52 to 4.29). Furthermore, the prevalence of the O1 serotype was higher among serum-resistant strains of both ESBL-producing (74%; 20/27isolates) and non-ESBL producers (75%; 24/32 isolates) than among serum-sensitive ESBL producers (52.4%; 33/63 isolates) and non-ESBL producers (27.4%; 40/146 isolates). Serum resistance among ESBL-producing strains (36%; 17/47 isolates) versus non-ESBL-producing strains (16%; 27/166 isolates) was also significantly higher after the exclusion of clonal strains (P = 0.0056; OR = 2.9; 95% CI = 1.41 to 6.01). Sixteen ESBL types were detected, among which the frequency of serum resistance was significantly lower among the SHV-producing strains (9/48 isolates) than among the TEM producers (16/35 isolates) (P = 0.016; OR = 3.65; CI = 1.3 to 9.7). Curing ESBL-coding plasmids did not influence the serum resistance of the bacteria; all six plasmid-cured derivatives maintained serum resistance. The present findings suggest that ESBL-producing strains have a greater pathogenic potential than non-ESBL-producing strains, but the linkage between O serotypes, serum resistance, and ESBL production remains unclear at this stage.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-10449457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-10582907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-1107450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-11796363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-12199849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-12621091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-1345909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-1587619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-3263690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-3312009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-3531020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-3804440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-6195306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-6343827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-7526122,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-825532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-8432605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-8675336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-8712771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-8818891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-8889716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-8890232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-9158741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-9163469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-9302204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-9646106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-9675457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-9767057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328114-9854064
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0066-4804
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pubmed:author |
pubmed-author:AuckenHH,
pubmed-author:BenedíV JVJ,
pubmed-author:ForestierCC,
pubmed-author:FussingVV,
pubmed-author:HansenD SDS,
pubmed-author:OfekII,
pubmed-author:PodschunRR,
pubmed-author:SahlyHH,
pubmed-author:SandvangDD,
pubmed-author:SirotDD,
pubmed-author:TomásJ MJM,
pubmed-author:UllmannUU
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3477-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15328114-Blood Bactericidal Activity,
pubmed-meshheading:15328114-DNA, Bacterial,
pubmed-meshheading:15328114-DNA Primers,
pubmed-meshheading:15328114-Drug Resistance, Bacterial,
pubmed-meshheading:15328114-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15328114-Humans,
pubmed-meshheading:15328114-Klebsiella pneumoniae,
pubmed-meshheading:15328114-Plasmids,
pubmed-meshheading:15328114-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15328114-Ribotyping,
pubmed-meshheading:15328114-Serotyping,
pubmed-meshheading:15328114-beta-Lactamases
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pubmed:year |
2004
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pubmed:articleTitle |
Increased serum resistance in Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases.
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pubmed:affiliation |
Department of Medical Microbiology and Virology, University of Kiel, Brunswiker Str. 4, 24105 Kiel, Germany. sahly@medmicrobio.uni-kiel.de
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pubmed:publicationType |
Journal Article
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