Linked Life Data

15328090

Source:http://linkedlifedata.com/resource/pubmed/id/15328090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2004-8-25
pubmed:abstractText
To investigate the effects of posaconazole (POS) and amphotericin B (AMB) combination therapy in cryptococcal infection, we established an experimental model of systemic cryptococcosis in CD1 mice by intravenous injection of three distinct clinical isolates of Cryptococcus neoformans. Therapy was started 24 h after the infection and continued for 10 consecutive days. POS was given at 3 and 10 mg/kg of body weight/day, while AMB was given at 0.3 mg/kg/day. Combination therapy consisted of POS given at a low (combo 3) or at a high (combo 10) dose plus AMB. Survival studies showed that combo 3 was significantly more effective than POS at 3 mg/kg for two isolates tested (P value, < or = 0.001), while combo 10 was significantly more effective than POS at 10 mg/kg for all three isolates (P values ranging from <0.001 to 0.005). However, neither combination regimen was more effective than AMB alone. For two isolates, combination therapy was significantly more effective than each single drug at reducing the fungal burden in the brain (P values ranging from 0.001 to 0.015) but not in the lungs. This study demonstrates that the major impact of POS and AMB combination therapy is on brain fungal burden rather than on survival.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-10508027, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-10770733, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-10952592, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-11302795, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-11698718, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-12746765, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-14982754, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-14982761, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-14982793, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-449951, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-6255531, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-6286799, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-6327836, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-7793858, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-8665468, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-8953097, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-9145879, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-9174196, http://linkedlifedata.com/resource/pubmed/commentcorrection/15328090-9607846
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3312-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Posaconazole and amphotericin B combination therapy against Cryptococcus neoformans infection.
pubmed:affiliation
Istituo di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliera Umberto I, Via Conca, 60020 Torrette di Ancona, Ancona, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't