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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-5-14
|
| pubmed:abstractText |
We have studied the phenotype and activation status of leukocytes in the bronchial mucosa in patients with isocyanate-induced asthma. Fiberoptic bronchial biopsy specimens were obtained from nine subjects with occupational (five toluene- and four methylene diisocyanate-sensitive) asthma, 10 subjects with extrinsic asthma, and 12 nonatopic healthy control subjects. Bronchial biopsy specimens were examined by immunohistology with a panel of monoclonal antibodies and the alkaline phosphatase-antialkaline phosphatase method. There was a significant increase in the number of CD25+ cells (interleukin-2 receptor-bearing cells, presumed "activated" T-lymphocytes; p less than 0.01) in isocyanate-induced asthma compared with that of control subjects. There were also significant increases in major basic protein (BMK-13)-positive (p less than 0.02) and EG2-positive (p less than 0.01) cells that represent total and "activated" eosinophil cationic protein-secreting eosinophils, respectively. In agreement with our previous findings, CD25+ (p less than 0.01), BMK-13 (p less than 0.03), and EG2+ (p less than 0.01) cells were also elevated in extrinsic asthma. No significant differences were observed in the numbers of T-lymphocyte phenotypic markers (CD3, CD4, and CD8) between subjects with asthma (isocyanate-induced and extrinsic) and control subjects. Similarly, no significant differences in immunostaining for neutrophil elastase (neutrophils) or CD68 (macrophages) were observed. The results suggest that isocyanate-induced occupational asthma and atopic (extrinsic) asthma have a similar pattern of inflammatory cell infiltrate. The results support the view that T-lymphocyte activation and eosinophil recruitment may be important in asthma of diverse etiology.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Cyanates,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0091-6749
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
89
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
821-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1532807-Adult,
pubmed-meshheading:1532807-Antigens, CD,
pubmed-meshheading:1532807-Antigens, CD45,
pubmed-meshheading:1532807-Asthma,
pubmed-meshheading:1532807-Biopsy,
pubmed-meshheading:1532807-Bronchi,
pubmed-meshheading:1532807-Cyanates,
pubmed-meshheading:1532807-Drug Hypersensitivity,
pubmed-meshheading:1532807-Eosinophils,
pubmed-meshheading:1532807-Female,
pubmed-meshheading:1532807-Histocompatibility Antigens,
pubmed-meshheading:1532807-Humans,
pubmed-meshheading:1532807-Immunohistochemistry,
pubmed-meshheading:1532807-Lymphocyte Activation,
pubmed-meshheading:1532807-Male,
pubmed-meshheading:1532807-Middle Aged,
pubmed-meshheading:1532807-Mucous Membrane,
pubmed-meshheading:1532807-Occupational Diseases,
pubmed-meshheading:1532807-Receptors, Interleukin-2,
pubmed-meshheading:1532807-T-Lymphocytes
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma.
|
| pubmed:affiliation |
Department of Allergy and Clinical Immunology, National Heart & Lung Institute, London, England.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|