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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2004-8-25
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pubmed:abstractText |
Glycoprotein 130 (gp130), a common receptor of IL-6 family cytokines, plays critical roles in cardiac functions. Here, we demonstrate that the stimulation of gp130 with leukemia inhibitory factor (LIF) promoted cell adhesion in a cadherin-dependent manner in cultured cardiomyocytes. Wnt5a was upregulated by the stimulation of gp130 with IL-6 family cytokines, accompanied by N-cadherin protein upregulation. Wnt5a was not induced by LIF in cardiomyocytes expressing dominant-negative STAT3. Ablation of Wnt5a by antisense cDNA inhibited LIF-induced cell adhesion. Collectively, signals through gp130 upregulate Wnt5a through STAT3, promoting the N-cadherin-mediated cell adhesion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokine Receptor gp130,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IL6ST protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Il6st protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/LIF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Leukemia Inhibitory Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Stat3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt5a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/cardiotrophin 1
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-5793
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pubmed:author |
pubmed-author:AzumaJunichiJ,
pubmed-author:FujioYasushiY,
pubmed-author:HirataMayoM,
pubmed-author:ItoTakashiT,
pubmed-author:KimuraRyusukeR,
pubmed-author:KishimotoTadamitsuT,
pubmed-author:MaedaMakikoM,
pubmed-author:MatsudaTakahisaT,
pubmed-author:MohriTomomiT,
pubmed-author:NakaokaYoshikazuY,
pubmed-author:OshimaYuichiY,
pubmed-author:TakataniTomokaT
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
573
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
202-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15327998-Animals,
pubmed-meshheading:15327998-Antigens, CD,
pubmed-meshheading:15327998-Cadherins,
pubmed-meshheading:15327998-Cell Adhesion,
pubmed-meshheading:15327998-Cell Aggregation,
pubmed-meshheading:15327998-Cell Line,
pubmed-meshheading:15327998-Cells, Cultured,
pubmed-meshheading:15327998-Cytokine Receptor gp130,
pubmed-meshheading:15327998-Cytokines,
pubmed-meshheading:15327998-DNA-Binding Proteins,
pubmed-meshheading:15327998-Humans,
pubmed-meshheading:15327998-Interleukin-6,
pubmed-meshheading:15327998-Leukemia Inhibitory Factor,
pubmed-meshheading:15327998-Membrane Glycoproteins,
pubmed-meshheading:15327998-Myocytes, Cardiac,
pubmed-meshheading:15327998-Proteins,
pubmed-meshheading:15327998-RNA, Messenger,
pubmed-meshheading:15327998-Rats,
pubmed-meshheading:15327998-STAT3 Transcription Factor,
pubmed-meshheading:15327998-Signal Transduction,
pubmed-meshheading:15327998-Trans-Activators,
pubmed-meshheading:15327998-Up-Regulation,
pubmed-meshheading:15327998-Wnt Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes.
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pubmed:affiliation |
Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, 1-6 Yamadaoka, Suita City, Osaka 565-0871, Japan. fujio@phs.osaka-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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