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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-8-25
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pubmed:abstractText |
Human B19 erythrovirus replicates in erythroid progenitors present in bone marrow and fetal tissues where partial oxygen tension is low. Here we show that infected human primary erythroid progenitor cells exposed to hypoxia (1% O2) in vitro increase viral capsid protein synthesis, virus replication, and virus production. Hypoxia-inducible factor-1 (HIF-1), the main transcription factor involved in the cellular response to reduced oxygenation, is shown to bind an HIF binding site (HBS) located in the distal part of the B19 promoter region, but the precise mechanism involved in the oxygen-sensitive upregulation of viral gene expression remains to be elucidated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
327
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15327892-Base Sequence,
pubmed-meshheading:15327892-Cell Hypoxia,
pubmed-meshheading:15327892-Cells, Cultured,
pubmed-meshheading:15327892-DNA-Binding Proteins,
pubmed-meshheading:15327892-Erythroid Precursor Cells,
pubmed-meshheading:15327892-Gene Expression Regulation, Viral,
pubmed-meshheading:15327892-Humans,
pubmed-meshheading:15327892-Hypoxia-Inducible Factor 1,
pubmed-meshheading:15327892-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:15327892-Molecular Sequence Data,
pubmed-meshheading:15327892-Nuclear Proteins,
pubmed-meshheading:15327892-Parvovirus B19, Human,
pubmed-meshheading:15327892-Transcription Factors,
pubmed-meshheading:15327892-Up-Regulation,
pubmed-meshheading:15327892-Viral Proteins,
pubmed-meshheading:15327892-Virus Replication
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pubmed:year |
2004
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pubmed:articleTitle |
Hypoxia enhances human B19 erythrovirus gene expression in primary erythroid cells.
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pubmed:affiliation |
Hôpital Saint-Louis, AP-HP, Virologie and CNRS UPR 9051, Paris, France. sylvie.pillet@univ-st-etienne.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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