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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
36
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pubmed:dateCreated |
2004-9-8
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pubmed:databankReference |
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pubmed:abstractText |
Lv1 restriction of HIV-1 in the cells of Old World monkeys is associated with the expression of the Trim5 gene. Uniquely, in owl monkey kidney cells, HIV-1 restriction is dependent on the ability of incoming viral capsid protein to bind cyclophilin A (CypA). Cloning of the owl monkey Trim5 gene now reveals the presence of an inserted CypA pseudogene within intron 7 of the Trim5 gene. This insertion results in the formation of a chimeric Trim5-CypA transcript. Transfer of a cDNA corresponding to this transcript into human cells confers cyclosporin A-sensitive resistance to HIV-1 infection. The restriction factor appears to be a chimeric protein created by retrotransposon-mediated exon shuffling.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15326303-10479675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15326303-10516044,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15326303-9223641
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13324-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15326303-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:15326303-Amino Acid Sequence,
pubmed-meshheading:15326303-Animals,
pubmed-meshheading:15326303-Aotidae,
pubmed-meshheading:15326303-Base Sequence,
pubmed-meshheading:15326303-Capsid Proteins,
pubmed-meshheading:15326303-Chromosome Mapping,
pubmed-meshheading:15326303-Cyclophilin A,
pubmed-meshheading:15326303-HIV-1,
pubmed-meshheading:15326303-Kidney,
pubmed-meshheading:15326303-Molecular Sequence Data,
pubmed-meshheading:15326303-Proteins,
pubmed-meshheading:15326303-RNA, Messenger,
pubmed-meshheading:15326303-Recombinant Fusion Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1.
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pubmed:affiliation |
Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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